Citrate-Based Fluorescent Biomaterials.
Citrate-Based Fluorescent Biomaterials.
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DOI：
10.1002/adhm.201800532
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发表时间：
2018-09
影响因子：
10
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Shan D;Hsieh JT;Bai X;Yang J
荧光成像已经成为一种有前途的技术，用于监测和评估细胞和生物体中的各种生物相关物种，推动了对具有良好生物相容性和高荧光性能的有效荧光剂的需求。然而，传统的荧光剂，如量子点（QD）和有机染料，或者受到毒性问题的困扰，或者受到差的荧光性能（例如，低的耐光漂白性）的困扰。在这方面，基于柠檬酸盐的荧光生物材料，它是从天然的和生物相容的柠檬酸（CA）的前体合成的，由于其生物相容性，成本效益，简单的合成路线，灵活的可设计性，以及具有可调的激发/发射波长的强荧光，已成为荧光成像的有竞争力的替代品。因此，在过去的几十年中，已经开发和研究了许多基于柠檬酸盐的生物材料，包括碳量子点（CD）、可生物降解的光致发光聚合物（BPLPs）和小分子荧光团。本文综述了近年来柠檬酸盐荧光材料的研究进展，重点介绍了柠檬酸盐荧光材料的设计与合成、材料性能、荧光性能与机理以及生物医学应用。我们期望这篇综述能为柠檬酸盐基荧光生物材料提供有见地的讨论，并为下一代荧光生物材料和基于荧光的生物医学技术带来创新。
Fluorescence imaging has emerged as a promising technique for monitoring and assessing various biologically relevant species in cells and organisms, driving the demand for effective fluorescent agents with good biocompatibility and high fluorescence performance. However, traditional fluorescent agents, such as quantum dots (QDs) and organic dyes, either suffer from toxicity concerns or poor fluorescence performance (e.g. low photobleaching-resistance). In this regard, citrate-based fluorescent biomaterials, which are synthesized from the natural and biocompatible precursor of citric acid (CA), have become competitive alternatives for fluorescence imaging owing to their biocompatibility, cost effectiveness, straightforward synthetic routes, flexible designability, as well as strong fluorescence with adjustable excitation/emission wavelengths. Accordingly, numerous citrate-based biomaterials, including carbon dots (CDs), biodegradable photoluminescent polymers (BPLPs), and small molecular fluorophores, have been developed and researched in the past decades. This review discusses recent progress in the research and development of citrate-based fluorescent materials with emphasis on their design and synthesis considerations, material properties, fluorescence properties and mechanisms, as well as biomedical applications. We expect that this review will provide an insightful discussion on the citrate-based fluorescent biomaterials, and lead to innovations for the next generation of fluorescent biomaterials and fluorescence-based biomedical technology.
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