Blood erythrocyte concentrations of cadmium and lead and the risk of B-cell non-Hodgkin's lymphoma and multiple myeloma: a nested case-control study.
Blood erythrocyte concentrations of cadmium and lead and the risk of B-cell non-Hodgkin's lymphoma and multiple myeloma: a nested case-control study.
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DOI：
10.1371/journal.pone.0081892
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
EnviroGenoMarkersProject Consortium
中科院分区：
文献类型：
--
作者：
Kelly RS;Lundh T;Porta M;Bergdahl IA;Palli D;Johansson AS;Botsivali M;Vineis P;Vermeulen R;Kyrtopoulos SA;Chadeau-Hyam M;EnviroGenoMarkersProject Consortium
镉(Cd)和铅(Pb)被认为是非霍奇金淋巴瘤(NHL)的危险因素，NHL是一组具有可疑环境病因的血液系统恶性肿瘤。在环境基因标记物研究中，我们利用诊断前红细胞中镉和铅的浓度来确定暴露是否与B细胞非霍奇金淋巴瘤和多发性骨髓瘤的风险有关。1990至2006年间确诊的194例B细胞非霍奇金淋巴瘤和76例多发性骨髓瘤病例是从两个现有的队列中确定的；EPIC-意大利和瑞典北部健康和疾病研究。根据中心、年龄、性别和采血日期将病例与健康对照组相匹配。用电感耦合等离子体质谱检测新兵入伍时提供的血样中的Cd和Pb值。采用Logistic回归分析来评估其与风险的关系。分析按队列和性别以及可能的子类型进行分层。在总人群中，几乎没有证据表明暴露于镉(B细胞NHL：OR 1.09 95%CI 0.61，1.93，MM：OR 1.16 95%CI：0.40，3.40)或铅(B细胞NHL：0.93 95%CI 0.43，2.02，多发性骨髓瘤：或1.63 95%CI 0.45，5.94)的总人群中，患B细胞性NHL或多发性骨髓瘤的风险增加。然而，性别和队列具体结果的差异被观察到。在女性中，身体负荷量为1微克/L的女性患B细胞性非霍奇金淋巴瘤的风险增加了一倍以上(OR 2.20，95%CI；1.04，4.65)。这项嵌套的病例对照研究并不支持镉或铅与非霍奇金淋巴瘤之间一致的正相关，但有一些迹象表明性别特有的影响表明有必要进行进一步的研究。
Cadmium (Cd) and lead (Pb) are hypothesised to be risk factors for non-Hodgkin’s lymphoma (NHL), a group of haematological malignancies with a suspected environmental aetiology. Within the EnviroGenoMarkers study we utilised pre-diagnostic erythrocyte concentrations of Cd and Pb to determine whether exposure was associated with risk of B-cell NHL and multiple myeloma. 194 incident cases of B-cell NHL and 76 cases of multiple myeloma diagnosed between 1990 and 2006 were identified from two existing cohorts; EPIC-Italy and the Northern Sweden Health and Disease Study. Cases were matched to healthy controls by centre, age, gender and date of blood collection. Cd and Pb were measured in blood samples provided at recruitment using inductively coupled plasma-mass spectrometry. Logistic regression was applied to assess the association with risk. Analyses were stratified by cohort and gender and by subtype where possible. There was little evidence of an increased risk of B-cell NHL or multiple myeloma with exposure to Cd (B-cell NHL: OR 1.09 95%CI 0.61, 1.93, MM: OR 1.16 95% CI: 0.40, 3.40 ) or Pb (B-cell NHL: 0.93 95% CI 0.43, 2.02, multiple myeloma: OR 1.63 95%CI 0.45, 5.94) in the total population when comparing the highest to the lowest quartile of exposure. However, gender and cohort specific differences in results were observed. In females the risk of B-cell NHL was more than doubled in those with a body burden of Cd >1µg/L (OR 2.20 95%CI; 1.04, 4.65). This nested case-control study does not support a consistent positive association between Cd or Pb and NHL, but there is some indication of a gender specific effect suggesting further research is warranted.
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DOI：
10.1158/1055-9965.epi-10-0125
发表时间：
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
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作者：
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