Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways.
Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways.
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母亲童年创伤对儿童情绪健康的影响：母亲心理健康和额杏仁核通路。
DOI：
10.1111/jcpp.13721
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Callaghan,BridgetL
中科院分区：
文献类型：
--
作者：
Uy,JessicaP;Tan,AiPeng;Broeckman,BiritBFP;Gluckman,PeterD;Chong,YapSeng;Chen,Helen;Fortier,MarielleV;Meaney,MichaelJ;Callaghan,BridgetL
背景早年逆境经历对暴露的个体构成重大的心理和身体健康风险。新出现的证据表明，这些健康风险可以代代相传；然而，母亲早年创伤对儿童健康的代际影响的机制仍不清楚。方法本研究采用前瞻性纵向设计来确定母亲童年创伤（忽视和虐待）和母亲产前和产后心理健康（焦虑和抑郁症状）（N= 541）对儿童6岁时静息额杏仁核功能连接（N= 89）和情绪健康的独特和共同贡献。 7-8岁，以父母报告的内化问题和儿童自我报告的焦虑和抑郁症状为索引（N= 268-418）。结果母亲童年时期更大的忽视与更严重的内化问题通过一条更差的母亲产前和产后心理健康状况（更严重的母亲焦虑和抑郁症状）间接相关。更糟糕的产妇产后心理健康状况也与更消极的儿童额杏仁核静息状态功能连接、产妇童年创伤（忽视和虐待）和产前心理健康有关。反过来，额杏仁核功能连接的负性与儿童情绪健康状况较差有关。结论当前研究的结果支持了父母童年创伤暴露对下一代儿童精神病理学风险的代际影响的存在，并指出了与第二代相关的母亲因素（母亲产前和产后心理健康）在确定母亲早期经历的代际影响中的重要性。
BackgroundExperiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early‐life trauma on child health remain unknown.MethodsThe current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N= 541) to children's resting frontoamygdala functional connectivity at 6 years (N= 89) and emotional health at 7–8 years, as indexed by parent‐reported internalizing problems and child self‐reported anxiety and depressive symptoms (N= 268–418).ResultsGreater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting‐state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes.ConclusionsFindings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences.
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DOI：
10.1016/j.bpsc.2016.03.003
发表时间：
2016-07
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
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作者：
通讯作者：
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影响因子：
4.6
作者：
Kopala-Sibley DC;Cyr M;Finsaas MC;Orawe J;Huang A;Tottenham N;Klein DN
通讯作者：
Klein DN
DOI：
10.1016/j.jaac.2020.01.024
发表时间：
2021-01-01
影响因子：
13.3
作者：
Gaffrey, Michael S.;Barch, Deanna M.;Petersen, Steven E.
通讯作者：
Petersen, Steven E.
影响因子：
3.7
作者：
Ducharme, Simon;Albaugh, Matthew D.;Karama, Sherif
通讯作者：
Karama, Sherif
影响因子：
--
作者：
Green, Jennifer Greif;McLaughlin, Katie A.;Berglund, Patricia A.;Gruber, Michael J.;Sampson, Nancy A.;Zaslavsky, Alan M.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.