Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging.
Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging.
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DOI：
10.1021/bc200162r
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发表时间：
2011-09-21
影响因子：
4.7
通讯作者：
Fahmy, Tarek M.
中科院分区：
文献类型：
--
作者：
Criscione, Jason M.;Dobrucki, Lawrence W.;Zhuang, Zhen W.;Papademetris, Xenophon;Simons, Michael;Sinusas, Albert J.;Fahmy, Tarek M.
通常应用混合或多模态成像，以便利用各个成像模态的独特和互补优势。这种混合非侵入性成像方法可以提供有关解剖结构的关键信息以及生理功能或目标分子信号。虽然软件图像融合技术和混合成像系统的最新进展已经实现了高效的多模态成像，但要充分发挥该技术的潜力，需要开发新的多模态造影剂工具箱来增强成像过程。为了实现这一目标，我们报告了一种用于单光子发射计算机断层扫描 (SPECT) 和 X 射线计算机断层扫描 (CT) 成像的混合探针的开发，该探针有助于高灵敏度 SPECT 和高空间分辨率 CT 成像。在这项工作中，我们报告了一种用于临床前 SPECT/CT 混合成像系统的新型血管内、多模式树枝状大分子造影剂的合成和评估。这种多模式试剂具有较长的血管内停留时间（t1/2 = 43 分钟）和足够的噪声对比，可通过 SPECT 和 CT 进行有效的连续血管内和血池成像。树突核和 X 射线对比的共定位提供了促进图像分析和量化的潜力，通过利用循环 CT 对比提供的更高分辨率的解剖信息在指定时间校正 SPECT 衰减和部分体积误差。这可以允许对心肌内血容量和血流量进行绝对定量，并且可以使得能够在从血液中清除后可视化活性分子靶向。
Hybrid or multi-modality imaging is often applied, in order to take advantage of the unique and complementary strengths of individual imaging modalities. This hybrid non-invasive imaging approach can provide both critical information about anatomical structure in combination with physiological function or targeted molecular signals. While recent advances in software image fusion techniques and hybrid imaging systems have enabled efficient multimodal imaging, accessing the full potential of this technique requires development of a new toolbox of multimodal contrast agents that enhance the imaging process. Toward that goal, we report the development of a hybrid probe for both single photon emission computed tomography (SPECT) and X-ray computed tomography (CT) imaging that facilitates high sensitivity SPECT and high spatial resolution CT imaging. In this work, we report the synthesis and evaluation of a novel intravascular, multimodal dendrimer-based contrast agent for use in pre-clinical SPECT/CT hybrid imaging systems. This multimodal agent offers a long intravascular residence time (t1/2 = 43 min) and sufficient contrast-to-noise for effective serial intravascular and blood pool imaging with both SPECT and CT. The co-localization of the dendritic nuclear and X-ray contrasts offers the potential to facilitate image analysis and quantification by enabling correction for SPECT attenuation and partial volume errors at specified times with the higher resolution anatomic information provided by the circulating CT contrast. This may allow absolute quantification of intramyocardial blood volume and blood flow and may enable the ability to visualize active molecular targeting following clearance from the blood.
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影响因子：
62.1
作者：
Louie, Angelique Y.
通讯作者：
Louie, Angelique Y.
影响因子：
3
作者：
Jaszberenyi, Zoltan;Moriggi, Loick;Toth, Eva
通讯作者：
Toth, Eva
影响因子：
5.5
作者：
Majoros, IJ;Keszler, B;Baker, JR
通讯作者：
Baker, JR
影响因子：
82.9
作者：
Judenhofer, Martin S.;Wehrl, Hans F.;Pichler, Bernd J.
通讯作者：
Pichler, Bernd J.
影响因子：
5.8
作者：
Banerjee, T;Singh, AK;Maitra, AN
通讯作者：
Maitra, AN