Relationship of circulating spexin with markers of cardiovascular disease: a pilot study in adolescents with obesity.
Relationship of circulating spexin with markers of cardiovascular disease: a pilot study in adolescents with obesity.
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DOI：
10.1111/ijpo.12249
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发表时间：
2018-06
影响因子：
3.8
通讯作者：
Balagopal PB
中科院分区：
文献类型：
--
作者：
Kumar S;Hossain MJ;Javed A;Kullo IJ;Balagopal PB
Spexin是一种新型肽，在肥胖、饱腹感和能量平衡中具有潜在的意义。本研究探讨了spexin与肥胖青少年心血管疾病（CVD）和内皮功能的各种生物标志物的关系。研究了19例肥胖青少年[年龄15.8±1.7岁]。测定Spexin、leptin及各种CVD生物标志物。采用高分辨率多普勒超声检查右肱动脉内皮功能。Spexin浓度[中位数（IQR） 0.38 ng/mL (0.29 ~ 0.59 ng/mL)]与瘦素呈负相关（r=-0.50， P=0.03）。当参与者被分成两组（“高speexin和低瘦素”vs“低speexin和高瘦素”）时，高hs-CRP（≥3mg/L）的参与者出现“低speexin和高瘦素”的几率是低hs-CRP （<3mg/L）参与者的12.25倍（95% CI- 1 - 139， P=0.026）。然而，Spexin水平与内皮功能测量无关。spexin和瘦素之间的负相关，以及在“低spexin和高瘦素”的情况下肥胖青少年中hs-CRP浓度较高的存在，表明spexin在肥胖儿童饱腹感和某些心血管危险因素的调节中具有潜在作用。
Spexin, a novel peptide, has potential implications in obesity, satiety and energy homeostasis. The current study examined the relationship of spexin with various biomarkers of cardiovascular disease (CVD) and endothelial function in adolescents with obesity. Nineteen adolescents with obesity [age, 15.8 ±1.7 years] were studied. Spexin, leptin and various CVD biomarkers were measured. Endothelial function was assessed by high-resolution Doppler ultrasonography of the right brachial artery. Spexin concentration [median (IQR) 0.38 ng/mL (0.29-0.59 ng/mL)] was inversely correlated (r=-0.50, P=0.03) with leptin. When participants were clustered into two groups (“high spexin and low leptin” vs. “low spexin and high leptin”), the odds of having “low spexin and high leptin” in participants with higher hs-CRP (≥ 3mg/L) was 12.25 times (95% CI- 1 to139, P=0.026) higher than that of participants with lower hs-CRP (<3mg/L). Spexin levels, however, were not associated with measures of endothelial function. The inverse association between spexin and leptin and the presence of higher concentrations of hs-CRP in adolescents with obesity in the setting of “low spexin and high leptin” suggest a potential role for spexin in the regulation of satiety and certain cardiovascular risk factors in children with obesity.
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影响因子：
6.9
作者：
Balagopal, Prabhakaran (Babu);Gidding, Samuel S.;Funanage, Vicky L.
通讯作者：
Funanage, Vicky L.
影响因子：
3.8
作者：
Tobisch, B.;Blatniczky, L.;Barkai, L.
通讯作者：
Barkai, L.
影响因子：
5.8
作者：
Kumar, Seema;Hossain, Jobayer;Balagopal, P. Babu
通讯作者：
Balagopal, P. Babu
DOI：
10.1161/01.atv.0000024222.06463.21
发表时间：
2002-08-01
影响因子：
8.7
作者：
Järvisalo, MJ;Harmoinen, A;Raitakari, OT
通讯作者：
Raitakari, OT
影响因子：
120.7
作者：
Heymsfield, SB;Greenberg, AS;McCamish, M
通讯作者：
McCamish, M