Human lesions and animal studies link the claustrum to perception, salience, sleep and pain.
Human lesions and animal studies link the claustrum to perception, salience, sleep and pain.
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DOI：
10.1093/brain/awac114
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发表时间：
2022-06-03
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--
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屏状核是人脑中互连最密集的区域。尽管临床和实验研究的数据不断积累，屏状核的功能作用仍然未知。在这里，我们系统地回顾屏状核损伤研究并讨论其功能意义。幽闭病变与一系列体征和症状有关，包括认知、知觉和运动能力的变化；电活动；精神状态；然后睡觉。幽门损伤后观察到的广泛症状并没有提供令人信服的证据来支持当前著名的幽门功能理论，例如多感觉整合或显着性计算。相反，病变研究支持屏状核调节皮质兴奋性的假设。我们认为屏状核与执行基本和高级认知功能的多个大脑网络相连，或者是多个大脑网络的一部分。作为众多网络中的多功能节点，这可以解释屏状核损伤对大脑和行为的多种影响。屏状核是人脑中互连最密集的区域。通过回顾有关人类屏状核损伤的文献并将其与最近的动物研究爆炸性联系起来，Atilgan 等人。认为屏状核通过其在不同网络中的不可或缺的作用而有助于感知、疼痛、睡眠和显着性。
The claustrum is the most densely interconnected region in the human brain. Despite the accumulating data from clinical and experimental studies, the functional role of the claustrum remains unknown. Here, we systematically review claustrum lesion studies and discuss their functional implications. Claustral lesions are associated with an array of signs and symptoms, including changes in cognitive, perceptual and motor abilities; electrical activity; mental state; and sleep. The wide range of symptoms observed following claustral lesions do not provide compelling evidence to support prominent current theories of claustrum function such as multisensory integration or salience computation. Conversely, the lesions studies support the hypothesis that the claustrum regulates cortical excitability. We argue that the claustrum is connected to, or part of, multiple brain networks that perform both fundamental and higher cognitive functions. As a multifunctional node in numerous networks, this may explain the manifold effects of claustrum damage on brain and behaviour. The claustrum is the most densely interconnected region in the human brain. By reviewing the literature on human lesions of the claustrum and linking it to the recent explosion in animal research, Atilgan et al. argue that the claustrum contributes to perception, pain, sleep and salience via its integral roles in different networks.
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