Functioning of neural systems supporting emotion regulation in anxiety-prone individuals.
Functioning of neural systems supporting emotion regulation in anxiety-prone individuals.
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DOI：
10.1016/j.neuroimage.2010.07.041
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发表时间：
2011-01-01
期刊：
影响因子：
5.7
通讯作者：
Stein, Murray B.
中科院分区：
文献类型：
--
作者：
Campbell-Sills, Laura;Simmons, Alan N.;Lovero, Kathryn L.;Rochlin, Alexis A.;Paulus, Martin P.;Stein, Murray B.
先前的神经影像学研究表明，前额叶皮层（PFC）对杏仁核和相关边缘结构的调节是努力情绪调节的潜在神经基质。易焦虑的个体会经历过多的负面情绪，这表明支持负面情绪下调的系统可能出现功能障碍。我们检验了焦虑个体需要增加外侧和内侧PFC的招募来减少负面情绪的假设。在功能磁共振成像（fMRI）过程中提出了一项情绪调节任务，该任务涉及观看中度负面图像。特质焦虑得分较高的参与者（n = 13）和正常特质焦虑得分的参与者（n = 13）接受了认知重评来减少负面情绪的训练。血氧水平依赖性（BOLD）的变化在参与者减少情绪和保持情绪时进行了对比。与健康对照组相比，焦虑的参与者在消极情绪的下调过程中表现出与努力（侧PFC）和自动（亚属前扣带皮层）情绪控制有关的大脑区域的更大激活。在焦虑参与者中，左腹外侧PFC活动与自我报告的更大的痛苦减少有关，但在健康对照组中没有。这些发现为焦虑易感个体情绪调节的神经基质功能改变提供了证据。焦虑的参与者需要更多的外侧和内侧PFC参与，以成功地减少负面情绪。
Previous neuroimaging studies suggest that prefrontal cortex (PFC) modulation of the amygdala and related limbic structures is an underlying neural substrate of effortful emotion regulation. Anxiety-prone individuals experience excessive negative emotions, signaling potential dysfunction of systems supporting down-regulation of negative emotions. We examined the hypothesis that anxious individuals require increased recruitment of lateral and medial PFC to decrease negative emotions. An emotion regulation task that involved viewing moderately negative images was presented during functional magnetic resonance imaging (fMRI). Participants with elevated trait anxiety scores (n = 13) and normal trait anxiety scores (n = 13) were trained to reduce negative emotions using cognitive reappraisal. Blood oxygenation level-dependent (BOLD) changes were contrasted for periods when participants were reducing emotions versus when they were maintaining emotions. Compared to healthy controls, anxious participants showed greater activation of brain regions implicated in effortful (lateral PFC) and automatic (subgenual anterior cingulate cortex) control of emotions during down-regulation of negative emotions. Left ventrolateral PFC activity was associated with greater self-reported reduction of distress in anxious participants, but not in healthy controls. These findings provide evidence of altered functioning of neural substrates of emotion regulation in anxiety-prone individuals. Anxious participants required greater engagement of lateral and medial PFC in order to successfully reduce negative emotions.
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