The Human Skin-Derived Precursors for Regenerative Medicine: Current State, Challenges, and Perspectives.
The Human Skin-Derived Precursors for Regenerative Medicine: Current State, Challenges, and Perspectives.
复制标题
再生医学的人类皮肤源性前体：现状、挑战和前景
DOI：
10.1155/2018/8637812
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发表时间：
2018
影响因子：
4.3
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Dai R;Hua W;Xie H;Chen W;Xiong L;Li L
皮肤来源的前体细胞（SKPs）是一种具有自我更新和多向分化潜能的成体干细胞来源。虽然啮齿动物SKPs已在大量研究中详细讨论，但人类SKPs（hSKPs）很少报道。了解hSKPs的生物学特性和可能的机制对再生医学特别是临床应用具有重要意义，因为人源性来源更适合于临床移植。hSKPs衍生物，如神经和中胚层后代，在没有任何遗传修饰的情况下具有体外和体内功能的发现使得hSKPs成为基于细胞的治疗的可靠、安全和可获得的资源。在这里，我们提供了一个概述hSKPs，描述他们的特点，起源和利基，和潜在的应用。还介绍了用于hSKPs的传统和创新培养方法之间的比较。此外，我们还讨论了hSKPs领域面临的挑战和未来的前景。通过这篇综述，我们希望指出hSKPs目前所处的阶段，并强调在这一领域仍然存在的问题。
Skin-derived precursors (SKPs) are an adult stem cell source with self-renewal and multipotent differentiation. Although rodent SKPs have been discussed in detail in substantial studies, human SKPs (hSKPs) are rarely reported. Understanding the biological properties and possible mechanisms underlying hSKPs has important implications for regenerative medicine particularly clinical applications, as human-derived sources are more suitable for clinical transplantation. The finding that hSKPs derivatives, such as neural and mesodermal progeny, have both in vitro and in vivo function without any genetical modification makes hSKPs a trustable, secure, and accessible resource for cell-based therapy. Here, we provide an overview of hSKPs, describing their characteristics, originations and niches, and potential applications. A comparison between traditional and innovative culture methods used for hSKPs is also introduced. Furthermore, we discuss the challenges and the future perspectives towards the field of hSKPs. With this review, we hope to point out the current stage of hSKPs and highlight the problems that remain in this field.
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影响因子：
5.9
作者：
Iribar H;Pérez-López V;Etxaniz U;Gutiérrez-Rivera A;Izeta A
通讯作者：
Izeta A
影响因子：
1.7
作者：
Dulak, Jozef;Szade, Krzysztof;Jozkowicz, Alicja
通讯作者：
Jozkowicz, Alicja
影响因子：
3.2
作者：
De Kock, Joery;Vanhaecke, Tamara;Snykers, Sarah
通讯作者：
Snykers, Sarah
影响因子：
21.3
作者：
Fernandes, KJL;McKenzie, IA;Miller, FD
通讯作者：
Miller, FD
影响因子：
5.9
作者：
Etxaniz, Usue;Perez-San Vicente, Adrian;Gago-Lopez, Nuria;Garcia-Dominguez, Mario;Iribar, Haizea;Aduriz, Ariane;Perez-Lopez, Virginia;Burgoa, Izaskun;Irizar, Haritz;Munoz-Culla, Maider;Vallejo-Illarramendi, Ainara;Leis, Olatz;Matheu, Ander;Martin, Angel G.;Otaegui, David;Paz Lopez-Mato, Maria;Gutierrez-Rivera, Araika;MacLellan, Robb;Izeta, Ander
通讯作者：
Izeta, Ander