Dose-dependent effects of isoflavone exposure during early lifetime on development and androgen sensitivity in male Wistar rats.
Dose-dependent effects of isoflavone exposure during early lifetime on development and androgen sensitivity in male Wistar rats.
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生命早期暴露异黄酮对雄性 Wistar 大鼠发育和雄激素敏感性的剂量依赖性影响
DOI：
10.1002/mnfr.201500559
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发表时间：
2016
影响因子：
5.2
通讯作者：
Diel P
中科院分区：
文献类型：
--
作者：
Müller D;Basso F;Kurrat A;Soukup ST;Niehoff A;Kulling SE;Diel P
范围我们研究的目的是调查青春期暴露于ISO对雄性Wistar大鼠各种生理终点的雄激素敏感性的剂量依赖性影响。将大鼠暴露于ISO耗尽饮食（IDD）或富含不同浓度大豆基ISO提取物的两种饮食之一，导致平均观察到的血浆浓度（ISO-丰富的饮食[IRD]低）和最大（IRD高）亚洲男性。大多数大鼠在出生后第81天（PND）进行睾丸切除术，并在PND 89至99天期间接受丙酸睾酮（TP）或溶媒给药。在完整大鼠（PND 99）的体重，食物摄入量，脂肪量没有受到ISO的影响，但血清甘油三酯和肝脂肪酸合成酶的表达下降。IRD低大鼠的松质骨矿物质密度（BMD）降低，但IRD高大鼠的BMD未降低。睾丸切除术（ORX）引起BMD的损失，这是拮抗IRD高。ISO增加精囊腺和提肛肌对雄激素的敏感性。此外，ISO血浆水平降低ORX相比，完整和TP-治疗rates.ConclusionIn总结，本研究的结果表明，暴露于ISO在青春期影响骨稳态，脂质代谢，并调节雄激素敏感性在年轻的成年雄性大鼠。
ScopeThe aim of our study was to investigate dose‐dependent effects of isoflavone (ISO) exposure during adolescence on the androgen sensitivity of various physiological end points in male Wistar rats.Methods and resultsDuring embryogenesis and adolescence, rats were exposed to an ISO‐depleted diet (IDD) or one of two diets enriched with different concentrations of a soy‐based ISO extract causing plasma concentrations observed averagely (ISO‐rich diet [IRD]low) and maximally (IRDhigh) in Asian men. Most of the rats were orchiectomized at postnatal day (PND) 81 and were treated with testosterone propionate (TP) or vehicle from PND 89 to 99. In intact rats (PND 99) body weight, food intake, and fat mass were not influenced by ISO, but serum triglycerides and hepatic fatty acid synthase expression were decreased. Trabecular bone mineral density (BMD) was reduced in IRDlow, but not in IRDhigh rats. Orchiectomy (ORX) induced loss of BMD, which was antagonized by IRDhigh. ISO increased androgen sensitivity of seminal vesicle and levator ani. Besides, ISO plasma levels were reduced by ORX compared to intact and TP‐treated rats.ConclusionIn summary, the results of this study indicate that exposure to ISO during adolescence affects bone homeostasis, lipid metabolism, and modulates androgen sensitivity in young adult male rats.
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影响因子：
4.8
作者：
G. Kuiper;J. Lemmen;B. Carlsson;J. Corton;S. Safe;P. T. van der Saag;B. van der Burg;J. Gustafsson-J.-Gus
通讯作者：
G. Kuiper;J. Lemmen;B. Carlsson;J. Corton;S. Safe;P. T. van der Saag;B. van der Burg;J. Gustafsson-J.-Gus
影响因子：
9.8
作者：
Fujioka, Maiko;Sudo, Yumi;Ishimi, Yoshiko
通讯作者：
Ishimi, Yoshiko
影响因子：
0.9
作者：
Lu, D. Y.;Li, Y.;Li, X. J.
通讯作者：
Li, X. J.
膳食补充大豆异黄酮或用大豆蛋白替代可防止大鼠肝脏脂滴积累并改变参与脂质代谢的基因表达
影响因子：
3.5
作者：
C. Xiao;Carla M. Wood;D. Weber;S. Aziz;R. Mehta;P. Griffin;K. Cockell
通讯作者：
K. Cockell
影响因子：
15.9
作者：
Hudgins, LC;Hellerstein, M;Hirsch, J
通讯作者：
Hirsch, J