Neuronal signature of spatial decision-making during navigation by freely moving rats by using calcium imaging.
Neuronal signature of spatial decision-making during navigation by freely moving rats by using calcium imaging.
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DOI：
10.1073/pnas.2212152119
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发表时间：
2022-11
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
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这份手稿解决了一个长期存在的问题，即位置细胞放电如何有助于空间环境中的导航，而来自在线钙成像的数据提供了一个新的解决方案。这些数据支持这样的观点，即在进入动物每天只会导航到几个可能位置中的一个的竞技场之前，包括位置细胞在内的空间响应细胞群在最后5 s期间放电。这个种群被证明是预测的目的地和轨迹，动物即将采取。空间记忆的一个挑战是理解位置细胞放电如何有助于导航决策。创建了一个空间近因任务，其中自由移动的大鼠首先在几天内熟悉了空间背景，此后要求编码，然后选择性地回忆当天被选择奖励的三个特定位置之一。钙成像用于记录5只大鼠在日常任务的探索、取样和选择阶段海马CA 1区的1,000多个细胞。关键的发现是，在进入竞技场之前的短时间内，启动框中的神经活动稳步上升，并且这种选择性群体细胞放电在正确的试验中预测了每天变化的目标，但在动物犯错误的试验中则不然。单细胞和群体活动的措施集中在这样一个想法，即神经活动的前瞻性编码可以参与导航决策。
This manuscript addresses a longstanding problem about how place cell firing contributes to navigation in spatial environments, and data derived from on-line calcium imaging offer a new solution. These data support the view that prior to entering an arena where an animal will navigate to only one of several possible places on each day, a population of spatially responsive cells, including place cells, fire during the last 5 s. This population is shown to be predictive of the destination and trajectory that the animal is about to take. A challenge in spatial memory is understanding how place cell firing contributes to decision-making in navigation. A spatial recency task was created in which freely moving rats first became familiar with a spatial context over several days and thereafter were required to encode and then selectively recall one of three specific locations within it that was chosen to be rewarded that day. Calcium imaging was used to record from more than 1,000 cells in area CA1 of the hippocampus of five rats during the exploration, sample, and choice phases of the daily task. The key finding was that neural activity in the startbox rose steadily in the short period prior to entry to the arena and that this selective population cell firing was predictive of the daily changing goal on correct trials but not on trials in which the animals made errors. Single-cell and population activity measures converged on the idea that prospective coding of neural activity can be involved in navigational decision-making.
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影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
DOI：
10.1523/jneurosci.2862-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fenton AA;Kao HY;Neymotin SA;Olypher A;Vayntrub Y;Lytton WW;Ludvig N
通讯作者：
Ludvig N
影响因子：
16.2
作者：
Leutgeb, JK;Leutgeb, S;Moser, EI
通讯作者：
Moser, EI
影响因子：
25
作者：
Karlsson, Mattias P.;Frank, Loren M.
通讯作者：
Frank, Loren M.
DOI：
10.1523/jneurosci.1378-09.2009
发表时间：
2009-08-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Komorowski RW;Manns JR;Eichenbaum H
通讯作者：
Eichenbaum H