Challenges and opportunities for structural DNA nanotechnology.

Challenges and opportunities for structural DNA nanotechnology.
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DOI:
10.1038/nnano.2011.187
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发表时间:
2011-11-06
影响因子:
38.3
通讯作者:
--
中科院分区:
材料科学1区
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--
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过去 30 年来,DNA 分子已被用来构建各种纳米级结构和设备,潜在的应用已经开始显现。但更先进的结构和应用的开发需要解决许多问题,其中最重要的是DNA的高成本和自组装的高错误率。在这里,我们研究了结构 DNA 纳米技术领域的技术挑战,并概述了如果能够克服这些障碍,可以开发的一些有前途的应用。我们特别强调 DNA 纳米结构在分子和细胞生物物理学、仿生系统、能量转移和光子学以及人类健康诊断和治疗中的潜在用途。
DNA molecules have been used to build a variety of nanoscale structures and devices over the past 30 years, and potential applications have begun to emerge. But the development of more advanced structures and applications will require a number of issues to be addressed, the most significant of which are the high cost of DNA and the high error rate of self-assembly. Here we examine the technical challenges in the field of structural DNA nanotechnology and outline some of the promising applications that could be developed if these hurdles can be overcome. In particular, we highlight the potential use of DNA nanostructures in molecular and cellular biophysics, as biomimetic systems, in energy transfer and photonics, and in diagnostics and therapeutics for human health.
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