Biomechanical parameters of the cornea measured with the Ocular Response Analyzer in normal eyes.
Biomechanical parameters of the cornea measured with the Ocular Response Analyzer in normal eyes.
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DOI：
10.1186/1471-2415-14-11
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发表时间：
2014-01-30
影响因子：
2
通讯作者：
Garway-Heath DF
中科院分区：
文献类型：
--
作者：
Kotecha A;Russell RA;Sinapis A;Pourjavan S;Sinapis D;Garway-Heath DF
目的探讨Reichert眼反应分析仪（ORA）参数角膜滞后（CH）和角膜反应因子（CRF）与眼大小、年龄和眼压的关系。212例无眼部病变的受试者中有212只眼睛用ORA测量了CH和CRF。用动态轮廓眼压计测量眼压，并评估中央角膜厚度。进行偏最小二乘线性回归（PLSLR）分析，以检查每个响应变量，CH和CRF，以及预测变量年龄，角膜曲率（CC），眼轴长度（AL），CCT和IOP之间的关系。CH与CCT呈正相关，与年龄呈负相关（比例系数：CCT 0.62，p < 0.0001;年龄-0.55，p <0.0001; r2 = 0.25）。CRF与CCT和DCT IOP呈正相关，与年龄和AL呈负相关（比例系数：CCT 0.89，p < 0.0001; DCT IOP 0.46，p < 0.01;年龄-0.60，p < 0.0001; AL-0.37，p < 0.01; r2 = 0.43）。CC与CH或CRF之间无显著相关性。研究表明，年龄和CCT与CH和CRF密切相关，后者也受AL和IOP的影响。然而，研究的变量只能解释25%和43%的CH和CRF，分别测量的变化，这表明其他因素也影响这些测量值。
To evaluate the relationships between Reichert Ocular Response Analyzer (ORA) parameters corneal hysteresis (CH) and corneal response factor (CRF) and ocular dimensions, age and intraocular pressure. Two hundred and twelve eyes of 212 participants with no ocular pathology had CH and CRF measured with the ORA. Intraocular pressure (IOP) was measured with the Dynamic Contour tonometer and central corneal thickness (CCT) was also evaluated. Partial least squares linear regression (PLSLR) analyses were performed to examine the relationships between each response variable, CH and CRF, and the predictor variables age, corneal curvature (CC), axial length (AL), CCT and IOP. CH was positively associated with CCT and negatively associated with age (scaled coefficients: CCT 0.62, p < 0.0001; age -0.55, p <0.0001; r2 = 0.25). CRF was positively associated with CCT and DCT IOP and negatively associated with age and AL (scaled coefficients: CCT 0.89, p < 0.0001; DCT IOP 0.46, p < 0.01; age – 0.60, p < 0.0001; AL -0.37, p < 0.01; r2 = 0.43). There was no significant association between CC and CH or CRF. The study suggests that age and CCT are strongly associated with CH and CRF, and that the latter is also influenced by AL and IOP. However, the variables studied could explain only 25% and 43% of the measured variation in CH and CRF, respectively, suggesting other factors also affect the values of these measurements.
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影响因子：
4.2
作者：
Congdon, NG;Broman, AT;Quigley, HA
通讯作者：
Quigley, HA
影响因子：
13.7
作者：
Narayanaswamy, Arun;Chung, Ronald S.;Aung, Tin
通讯作者：
Aung, Tin
影响因子：
4.4
作者：
Kotecha, Aachal;Crabb, David P.;Garway-Heath, David F.
通讯作者：
Garway-Heath, David F.
影响因子：
4.4
作者：
Boehm, Andreas G.;Weber, Anja;Spoerl, Eberhard
通讯作者：
Spoerl, Eberhard
影响因子：
4.4
作者：
Lim, Laurence;Gazzard, Gus;Saw, Seang-Mei
通讯作者：
Saw, Seang-Mei