Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation.
Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation.
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DOI：
10.1016/j.jare.2022.05.003
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发表时间：
2023-03
影响因子：
10.7
通讯作者：
Chen, Wei
中科院分区：
文献类型：
--
作者：
Tian, Peijun;Zou, Renying;Wang, Luyao;Chen, Ying;Qian, Xin;Zhao, Jianxin;Zhang, Hao;Qian, Long;Wang, Qun;Wang, Gang;Chen, Wei
益生菌降低了MDD患者的抑郁评分。益生菌可改善MDD患者的胃肠道问题。益生菌对患者的肠道微生物组造成轻微干扰。益生菌改善了应激小鼠的肠道运动。益生菌的肠道-大脑有益作用与它们对血清素的调节有关。重度抑郁症（MDD）是一种全球性的精神疾病。MDD与胃肠道异常高度共病，如肠道动力障碍。一个有效的策略来管理抑郁症及其伴随的胃肠道症状是必要的。三种益生菌菌株（短双歧杆菌CCFM1025、长双歧杆菌CCFM687和乳酸片球菌CCFM6432）先前已在小鼠中验证具有抗抑郁样潜力。本研究调查了联合三株益生菌干预对人类MDD患者的潜在精神作用。在应激抑郁小鼠模型中进一步研究其作用机制。MDD患者被给予冷冻干燥的混合益生菌配方四周。治疗前后采用临床评定量表对患者的心理和胃肠道状况进行评定。还使用16S rRNA基因扩增子测序分析了他们的肠道微生物组。使用慢性应激诱导的抑郁小鼠模型来确定益生菌有益作用的潜在机制。复合益生菌显著降低了抑郁评分，并且在更大程度上比安慰剂（基于汉密尔顿抑郁评分，蒙哥马利-阿斯伯格抑郁评分和简明精神病评定量表）。复合益生菌还显著改善了患者的胃肠道功能（基于使用胃肠道症状评定量表的自我评估）。5-羟色胺能系统修饰被证明是益生菌对大脑和肠道有益的关键机制。我们的研究结果表明，一种新的和有前途的治疗方法来管理MDD和伴随的肠道动力问题，并提供治疗其他肠脑轴相关疾病的选择。
Probiotics reduced the depression rating scores of MDD patients. Probiotics ameliorate the gastrointestinal problems of MDD patients. Probiotics caused slight perturbation on the patients’ gut microbiome. Probiotics improved the gut motility of stressed mice. Probiotics’ gut-brain beneficial effect correlates to their regulation of serotonin. Major depressive disorder (MDD) is a leading global psychiatric disease. MDD is highly comorbid with gastrointestinal abnormalities, such as gut motility dysfunction. An effective strategy to manage depression and its accompanying gastrointestinal symptoms is warranted. Three probiotic strains (Bifidobacterium breve CCFM1025, Bifidobacterium longum CCFM687, and Pediococcus acidilactici CCFM6432) had previously been validated in mice to possess antidepressant-like potential. This study investigated the potential psychotropic effects of a combined three-strain probiotic intervention for human MDD patients. The mechanism of action was further investigated in the stress-induced depression mice model. MDD patients were given a freeze-dried, mixed probiotic formula for four weeks. The patients’ psychometric and gastrointestinal conditions were evaluated using clinical rating scales before and after treatment. Their gut microbiome was also analysed using 16S rRNA gene amplicon sequencing. The mechanisms underlying the beneficial probiotic effects were determined using a chronic stress-induced depressive mouse model. Multi-probiotics significantly reduced depression scores, and to a greater extent than the placebo (based on the Hamilton Depression Rating, Montgomery-Asberg Depression Rating, and Brief Psychiatric Rating Scales). Multi-probiotics also significantly improved the patients’ gastrointestinal functions (based on self-evaluation using the Gastrointestinal Symptom Rating Scale). Serotonergic system modification was demonstrated as the key mechanism behind the probiotics’ benefits for the brain and the gut. Our findings suggest a novel and promising treatment to manage MDD and accompanying gut motility problems, and provide options for treating other gut-brain axis-related disorders.
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DOI：
10.1016/j.ijchp.2020.07.007
发表时间：
2021-01-01
影响因子：
8.8
作者：
Bueno-Notivol, Juan;Gracia-Garcia, Patricia;Santabarbara, Javier
通讯作者：
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DOI：
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影响因子：
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Huang R;Wang K;Hu J
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影响因子：
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