PDGFB-targeted functional MRI nanoswitch for activatable T(1)-T(2) dual-modal ultra-sensitive diagnosis of cancer.
PDGFB-targeted functional MRI nanoswitch for activatable T(1)-T(2) dual-modal ultra-sensitive diagnosis of cancer.
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PDGFB靶向功能性MRI纳米开关用于可激活T1-T2双模态超灵敏癌症诊断
DOI：
10.1186/s12951-023-01769-7
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发表时间：
2023-01-06
影响因子：
10.2
通讯作者：
Zhang, Guilong
中科院分区：
文献类型：
--
作者：
Zhang, Ya'nan;Liu, Lu;Li, Wenling;Zhang, Caiyun;Song, Tianwei;Wang, Peng;Sun, Daxi;Huang, Xiaodan;Qin, Xia;Ran, Lang;Tian, Geng;Qian, Junchao;Zhang, Guilong
磁共振成像（MRI）作为目前最重要的成像方式之一，已被广泛用于临床准确的癌症诊断。然而，低信噪比（SNR）和肿瘤的低特异性继续构成重大挑战。受距离依赖性磁共振调谐（MRET）现象的启发，本文提出了一种基于肿瘤微环境（TME）激活的开关T1-T2双模MRI纳米开关，以实现肿瘤的灵敏早期诊断。基于掺锰二氧化硅包覆PDGFB-FMS（PDGFB-ferromoreoxide coated by Mn-doped silica，PDGFB-FMS），设计并制备了肿瘤特异性纳米开关，其可在TME中的高浓度GSH和低pH下降解，从而激活T1-T2双模MRI信号。肿瘤特异性开关-开启双模MRI纳米开关可显著提高SNR，并成功用于早期肿瘤的准确诊断，特别是原位前列腺癌。此外，纳米开关的全身递送不会造成血液或组织损伤，并且可以及时排出体外，表现出优异的生物安全性。总的来说，该策略是在设计关-开双模MRI纳米探针以提高成像精度的方向上迈出的重要一步，这为开发新的MRI探针开辟了新的途径。在线版本包含补充材料，可通过10.1186/s12951-023-01769-7获得。
As one of the most significant imaging modalities currently available, magnetic resonance imaging (MRI) has been extensively utilized for clinically accurate cancer diagnosis. However, low signal-to-noise ratio (SNR) and low specificity for tumors continue to pose significant challenges. Inspired by the distance-dependent magnetic resonance tuning (MRET) phenomenon, the tumor microenvironment (TME)-activated off–on T1–T2 dual-mode MRI nanoswitch is presented in the current study to realize the sensitive early diagnosis of tumors. The tumor-specific nanoswitch is designed and manufactured on the basis of PDGFB-conjugating ferroferric oxide coated by Mn-doped silica (PDGFB-FMS), which can be degraded under the high-concentration GSH and low pH in TME to activate the T1–T2 dual-mode MRI signals. The tumor-specific off–on dual-mode MRI nanoswitch can significantly improve the SNR and is used successfully for the accurate diagnosis of early-stage tumors, particularly for orthotopic prostate cancer. In addition, the systemic delivery of the nanoswitch did not cause blood or tissue damage, and it can be excreted out of the body in a timely manner, demonstrating excellent biosafety. Overall, the strategy is a significant step in the direction of designing off–on dual-mode MRI nanoprobes to improve imaging accuracy, which opens up new avenues for the development of new MRI probes. The online version contains supplementary material available at 10.1186/s12951-023-01769-7.
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影响因子：
254.7
作者：
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