Striatal and extrastriatal dopamine D2/D3 receptors in schizophrenia evaluated with [18F]fallypride positron emission tomography.
Striatal and extrastriatal dopamine D2/D3 receptors in schizophrenia evaluated with [18F]fallypride positron emission tomography.
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DOI：
10.1016/j.biopsych.2010.05.027
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发表时间：
2010-10-01
影响因子：
10.6
通讯作者：
Abi-Dargham, Anissa
中科院分区：
文献类型：
--
作者：
Kegeles, Lawrence S.;Slifstein, Mark;Xu, Xiaoyan;Urban, Nina;Thompson, Judy L.;Moadel, Tiffany;Harkavy-Friedman, Jill M.;Gil, Roberto;Laruelle, Marc;Abi-Dargham, Anissa
关键词：
多巴胺D2/D3受体结合的改变已在精神分裂症中报道，并且成像研究的荟萃分析显示纹状体中的适度升高。较新的放射性配体现在允许评估这些受体在纹状体外区域。我们使用PET与[18F]fallypride评估D2/D3受体在纹状体和纹状体外区域的精神分裂症。21例精神分裂症患者和22名匹配的健康对照者用HR+相机进行扫描。双组织室模型（2 TCM）和参考组织方法给出了BPND，BPP和BPF的结合电位，并在5个纹状体和8个纹状体外区域进行了组间比较。患者组的几个区域容积较低，PET数据经部分容积效应校正。BP值在三个区域组间存在差异。2种TCM的BPND值，患者组和对照组尾状核连合后分别为28.7 ± 6.8和25.3 ± 4.3，丘脑分别为2.9 ± 0.7和2.6 ± 0.4，钩回分别为1.8 ± 0.5和2.1 ± 0.7。D2/D3受体随年龄的损失被发现在纹状体和纹状体外区域，并在新皮质更大。我们的研究发现，纹状体和纹状体外区域的D2/D3受体的选择性改变，与一些但不是所有先前发表的报告一致。如前所述的纹状体，一个更敏感的成像方法研究多巴胺在精神分裂症的病理生理学的作用可能是评估神经递质水平，而不是在纹状体外区域的D2/D3受体水平。
Alterations in dopamine D2/D3 receptor binding have been reported in schizophrenia, and a meta-analysis of imaging studies has shown a modest elevation in striatum. Newer radioligands now allow the assessment of these receptors in extrastriatal regions. We used PET with [18F]fallypride to evaluate D2/D3 receptors in both striatal and extrastriatal regions in schizophrenia. Twenty-one patients with schizophrenia and 22 matched healthy controls were scanned with an HR+ camera. Two-tissue compartment modeling (2TCM) and the reference tissue method gave binding potentials BPND, BPP, and BPF which were compared between groups in five striatal and 8 extrastriatal regions. Several regional volumes were lower in the patient group, and PET data were corrected for partial volume effects. BP values differed in three regions between groups. BPND values from 2TCM in patients and controls respectively were 28.7 ± 6.8 and 25.3 ± 4.3 in post-commissural caudate, 2.9 ± 0.7 and 2.6 ± 0.4 in thalamus, and 1.8 ± 0.5 and 2.1 ± 0.7 in uncus. Loss of D2/D3 receptors with age was found in striatal and extrastriatal regions and was greater in neocortex. Our study found selective alterations in D2/D3 receptors in striatal and extrastriatal regions, consistent with some but not all previously published reports. As previously shown for the striatum, a more sensitive imaging approach for studying the role of dopamine in the pathophysiology of schizophrenia might be assessment of neurotransmitter levels rather than D2/D3 receptor levels in extrastriatal regions.
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影响因子：
4.8
作者：
Cohen, J D;Forman, S D;Noll, D C
通讯作者：
Noll, D C
DOI：
10.1097/00004647-199607000-00016
发表时间：
1996-07-01
影响因子：
6.3
作者：
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作者：
Kaasinen, V;Vilkman, H;Rinne, JO
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Rinne, JO
影响因子：
10.6
作者：
Glenthoj, Birte Y.;Mackeprang, Torben;Videbaek, Charlotte
通讯作者：
Videbaek, Charlotte
影响因子：
5.7
作者：
Lammertsma, AA;Hume, SP
通讯作者：
Hume, SP