Cognitive and Brain Activity Changes After Mnemonic Strategy Training in Amnestic Mild Cognitive Impairment: Evidence From a Randomized Controlled Trial.
Cognitive and Brain Activity Changes After Mnemonic Strategy Training in Amnestic Mild Cognitive Impairment: Evidence From a Randomized Controlled Trial.
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DOI：
10.3389/fnagi.2018.00342
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发表时间：
2018
影响因子：
4.8
通讯作者：
Bottino CMC
中科院分区：
文献类型：
--
作者：
Simon SS;Hampstead BM;Nucci MP;Duran FLS;Fonseca LM;Martin MDGM;Ávila R;Porto FHG;Brucki SMD;Martins CB;Tascone LS;Amaro E Jr;Busatto GF;Bottino CMC
背景资料：记忆策略训练（MST）已被证明可以改善遗忘型轻度认知障碍（a-MCI）的认知表现，然而，一些问题仍然没有解决。本研究的目的是使用随机对照设计复制早期的试点研究结果，并评估转移效应和大脑激活的变化。方法：将30例a-MCI患者随机分为MST组和健康教育组。在基线时，参与者完成了临床和神经心理学评估以及结构和功能磁共振成像（fMRI）。干预措施单独管理，包括四个会议，超过2周。MST教会患者使用三步过程来学习和回忆脸名关联。治疗后评估包括功能磁共振成像，一个单独的脸名关联任务，神经心理学测试，元记忆的措施。行为（即，非功能性磁共振成像）测量在1个月和3个月后重复。结果如下：在MST条件下的参与者表现出更大的改善措施的面孔名称记忆，并增加联想策略的使用，伴随着增加功能磁共振成像激活左前颞叶的影响。虽然所有参与者都报告说，在干预后，他们对日常记忆的满意度更高，但只有MST组报告说，他们的记忆能力有了显着改善。对其他神经心理学测试没有明显的远转移效应。结论：结果表明，患有a-MCI的患者不仅表现出MST的刺激特异性益处，而且他们似乎能够将训练转移到至少一些其他认知任务中。MST还促进了涉及面部处理、情景和语义记忆以及社会认知的大脑区域的使用，这些区域与训练所涉及的认知过程一致。
Background: Mnemonic strategy training (MST) has been shown to improve cognitive performance in amnestic mild cognitive impairment (a-MCI), however, several questions remain unresolved. The goal of the present study was to replicate earlier pilot study findings using a randomized controlled design and to evaluate transfer effects and changes in brain activation. Methods: Thirty patients with a-MCI were randomized into MST or education program. At baseline, participants completed clinical and neuropsychological assessments as well as structural and functional magnetic resonance imaging (fMRI). Interventions were administered individually and comprised four sessions, over 2 weeks. MST taught patients to use a three-step process to learn and recall face-name associations. Post-treatment assessment included fMRI, a separate face-name association task, neuropsychological tests, and measures of metamemory. Behavioral (i.e., non-fMRI) measures were repeated after one and 3-months. Results: Participants in the MST condition showed greater improvement on measures of face-name memory, and increased associative strategy use; effects that were accompanied by increased fMRI activation in the left anterior temporal lobe. While all participants reported greater contentment with their everyday memory following intervention, only the MST group reported significant improvements in their memory abilities. There was no clear indication of far-transfer effects to other neuropsychological tests. Conclusion: Results demonstrate that patients with a-MCI not only show stimulus specific benefits of MST, but that they appear capable of transferring training to at least some other cognitive tasks. MST also facilitated the use of brain regions that are involved in face processing, episodic and semantic memory, and social cognition, which are consonant with the cognitive processes engaged by training.
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影响因子：
14.5
作者：
Belleville, Sylvie;Clement, Francis;Gauthier, Serge
通讯作者：
Gauthier, Serge
影响因子：
2.4
作者：
Clare, L;Wilson, BA;Hodges, JR
通讯作者：
Hodges, JR
影响因子：
5.7
作者：
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
6.3
作者：
Belleville, Sylvie;Hudon, Carol;Gauthier, Serge
通讯作者：
Gauthier, Serge
影响因子：
48
作者：
Barnes, Deborah E.;Yaffe, Kristine
通讯作者：
Yaffe, Kristine