Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort.
Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort.
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在Zoe预测1个队列中，探索社会喷气lag与肠道微生物组成，饮食和心脏代谢健康之间的关系。
DOI：
10.1007/s00394-023-03204-x
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发表时间：
2023-12
影响因子：
5
通讯作者：
中科院分区：
文献类型：
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在这项研究中，我们在ZOE预测1队列(NCT03479866)中探索了社会时差(SJL)与肠道微生物组成、饮食和心脏代谢健康之间的关系。我们评估了人口统计学、饮食、心脏代谢、大便代谢组学和餐后代谢指标(n = 1002)。我们使用自我报告的习惯性睡眠(n = 934)来计算sjl( ≥ 1.5h的睡眠中期时间点与周末的差异)。我们测试了心脏代谢标志物和饮食(ANCOVA)在调整性别、年龄、BMI、种族和社会经济地位方面的组差异(SJL组与非SJL组)。我们使用机器学习和关联分析对至少20%的样本中存在的物种水平基因组箱进行了肠道微生物组成的比较。与非SJL组相比，SJL组(16%，n = 145)的男性比例(39%比25%)更高，睡眠者(平均睡眠 和lt； 7h；5%比3%)更短，而且更年轻(38.4 ± 11.3岁比46.8 ± 11.7岁)。SJL的9种肠道细菌的相对丰度较高，而8种肠道细菌的相对丰度较低(Q <； 0.2和绝对Cohen‘s Effect Size &Gt； 0.2)，这在一定程度上是由饮食调节的。SJL与不良的饮食质量(不太健康的植物性饮食指数)、较高的土豆和含糖饮料的摄入量、较低的水果和坚果的摄入量以及较高的炎症标记物(甘氨酸和IL-6)相比(P <； 0.05调整协变量)有关；经多次测试调整后为不显著。在以充足睡眠为主的队列中，SJL与更不利的肠道微生物群之间的新关联突出了SJL对健康的潜在影响。网上版载有补充材料，可在10.1007/s00394-023-03204-x查阅。
In this study, we explore the relationship between social jetlag (SJL), a parameter of circadian misalignment, and gut microbial composition, diet and cardiometabolic health in the ZOE PREDICT 1 cohort (NCT03479866). We assessed demographic, diet, cardiometabolic, stool metagenomics and postprandial metabolic measures (n = 1002). We used self-reported habitual sleep (n = 934) to calculate SJL (difference in mid-sleep time point of ≥ 1.5 h on week versus weekend days). We tested group differences (SJL vs no-SJL) in cardiometabolic markers and diet (ANCOVA) adjusting for sex, age, BMI, ethnicity, and socio-economic status. We performed comparisons of gut microbial composition using machine learning and association analyses on the species level genome bins present in at least 20% of the samples. The SJL group (16%, n = 145) had a greater proportion of males (39% vs 25%), shorter sleepers (average sleep < 7 h; 5% vs 3%), and were younger (38.4 ± 11.3y vs 46.8 ± 11.7y) compared to the no-SJL group. SJL was associated with a higher relative abundance of 9 gut bacteria and lower abundance of 8 gut bacteria (q < 0.2 and absolute Cohen’s effect size > 0.2), in part mediated by diet. SJL was associated with unfavourable diet quality (less healthful Plant-based Diet Index), higher intakes of potatoes and sugar-sweetened beverages, and lower intakes of fruits, and nuts, and slightly higher markers of inflammation (GlycA and IL-6) compared with no-SJL (P < 0.05 adjusted for covariates); rendered non-significant after multiple testing adjustments. Novel associations between SJL and a more disadvantageous gut microbiome in a cohort of predominantly adequate sleepers highlight the potential implications of SJL for health. The online version contains supplementary material available at 10.1007/s00394-023-03204-x.
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影响因子：
5.9
作者：
Liang F;Fu J;Xu Y;Wang Y;Qiu N;Ding K;Zeng J;Moore JB;Li R
通讯作者：
Li R
影响因子：
4.4
作者：
Groeger, JA;Zijlstra, FRH;Dijk, DJ
通讯作者：
Dijk, DJ
影响因子：
82.9
作者：
Berry SE;Valdes AM;Drew DA;Asnicar F;Mazidi M;Wolf J;Capdevila J;Hadjigeorgiou G;Davies R;Al Khatib H;Bonnett C;Ganesh S;Bakker E;Hart D;Mangino M;Merino J;Linenberg I;Wyatt P;Ordovas JM;Gardner CD;Delahanty LM;Chan AT;Segata N;Franks PW;Spector TD
通讯作者：
Spector TD
DOI：
10.1111/j.1467-789x.2012.01011.x
发表时间：
2012-10
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Blaak EE;Antoine JM;Benton D;Björck I;Bozzetto L;Brouns F;Diamant M;Dye L;Hulshof T;Holst JJ;Lamport DJ;Laville M;Lawton CL;Meheust A;Nilson A;Normand S;Rivellese AA;Theis S;Torekov SS;Vinoy S
通讯作者：
Vinoy S
影响因子：
2.8
作者：
Kantermann, Thomas;Duboutay, Francoise;Skene, Debra J.
通讯作者：
Skene, Debra J.