Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss.
Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss.
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耳蜗突触病和噪音引起的隐性听力损失
DOI：
10.1155/2016/6143164
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发表时间：
2016
影响因子：
3.1
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Shi L;Chang Y;Li X;Aiken S;Liu L;Wang J
最近的动物模型研究表明，不导致永久性阈移（PTS）的噪声暴露可引起内毛细胞（IHC）和I型传入听觉神经纤维（ANF）之间的突触周围的相当大的损害。这些突触的破坏不仅使受神经支配的ANF丧失功能，而且如果突触不能重建，也会导致螺旋神经节神经元的缓慢变性。ANF的这种损失应导致信号编码缺陷，其通过朝向连接低自发速率（SR）ANF的突触的损伤的偏置而加剧，所述低自发速率（SR）ANF已知对于噪声背景中的信号编码至关重要。由于没有PTS，这些功能缺陷无法使用常规听力学评估检测到，并且可能不为患有这些功能缺陷的受试者所知。这种没有灵敏度变化的听力功能缺陷通常被称为“噪声诱发的隐性听力损失（NIHHL）”。本文就噪声诱发的突触损伤机制、突触损伤的可逆性、动物实验中NIHHL的功能缺陷、人类实验中NIHHL的证据以及NIHHL的外周和中枢作用等几个关键问题作一简要综述。
Recent studies on animal models have shown that noise exposure that does not lead to permanent threshold shift (PTS) can cause considerable damage around the synapses between inner hair cells (IHCs) and type-I afferent auditory nerve fibers (ANFs). Disruption of these synapses not only disables the innervated ANFs but also results in the slow degeneration of spiral ganglion neurons if the synapses are not reestablished. Such a loss of ANFs should result in signal coding deficits, which are exacerbated by the bias of the damage toward synapses connecting low-spontaneous-rate (SR) ANFs, which are known to be vital for signal coding in noisy background. As there is no PTS, these functional deficits cannot be detected using routine audiological evaluations and may be unknown to subjects who have them. Such functional deficits in hearing without changes in sensitivity are generally called “noise-induced hidden hearing loss (NIHHL).” Here, we provide a brief review to address several critical issues related to NIHHL: (1) the mechanism of noise induced synaptic damage, (2) reversibility of the synaptic damage, (3) the functional deficits as the nature of NIHHL in animal studies, (4) evidence of NIHHL in human subjects, and (5) peripheral and central contribution of NIHHL.
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DOI：
10.1007/s10162-005-5029-6
发表时间：
2005-09-01
影响因子：
2.4
作者：
Bertoli, S;Smurzynski, J;Probst, R
通讯作者：
Probst, R
影响因子：
2.8
作者：
CHEN, C;NENOV, A;BOBBIN, RP
通讯作者：
BOBBIN, RP
影响因子：
2.5
作者：
Bourien, Jerome;Tang, Yong;Wang, Jing
通讯作者：
Wang, Jing
影响因子：
3
作者：
Eggermont, Jos J.
通讯作者：
Eggermont, Jos J.
DOI：
10.1016/j.clinph.2014.01.011
发表时间：
2014-09
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Bharadwaj HM;Shinn-Cunningham BG
通讯作者：
Shinn-Cunningham BG