Differential neural network configuration during human path integration.
Differential neural network configuration during human path integration.
复制标题
人类路径整合过程中的差异神经网络配置。
DOI：
10.3389/fnhum.2014.00263
复制
发表时间：
2014
影响因子：
2.9
通讯作者：
Iaria G
中科院分区：
文献类型：
--
作者：
Arnold AE;Burles F;Bray S;Levy RM;Iaria G
路径整合是人类和动物导航的基本技能。尽管最近在动物模型中解开路径整合的神经基础方面取得了进展，但对人类神经水平上的路径整合如何运作知之甚少。以前试图描述人类视觉路径整合所使用的神经机制的尝试表明，海马体在允许准确表现方面发挥着核心作用，这与动物数据的结果大致相似。然而，近年来，海马体的核心作用以及动物和人类共享路径整合的类似神经机制的观点都受到了质疑。本研究使用数据驱动分析来研究人类视觉路径整合过程中参与的神经系统，从而对整个大脑的神经活动进行无偏估计。我们的研究结果表明，人类采用共同的任务控制，注意力和空间工作记忆系统在额顶网络的路径整合。然而，在如何将这些系统配置成功能网络方面，个体存在差异。高性能的个人被发现更广泛地表达空间工作记忆系统在前额叶皮层，而低性能的个人从事allocentric记忆系统主要是在内侧枕颞区。这些研究结果表明，视觉路径整合在人类短距离内可以通过空间工作记忆系统主要从事前额叶皮层和任务控制网络招募的记忆系统的差异配置可能有助于解释个人偏见的空间学习策略。
Path integration is a fundamental skill for navigation in both humans and animals. Despite recent advances in unraveling the neural basis of path integration in animal models, relatively little is known about how path integration operates at a neural level in humans. Previous attempts to characterize the neural mechanisms used by humans to visually path integrate have suggested a central role of the hippocampus in allowing accurate performance, broadly resembling results from animal data. However, in recent years both the central role of the hippocampus and the perspective that animals and humans share similar neural mechanisms for path integration has come into question. The present study uses a data driven analysis to investigate the neural systems engaged during visual path integration in humans, allowing for an unbiased estimate of neural activity across the entire brain. Our results suggest that humans employ common task control, attention and spatial working memory systems across a frontoparietal network during path integration. However, individuals differed in how these systems are configured into functional networks. High performing individuals were found to more broadly express spatial working memory systems in prefrontal cortex, while low performing individuals engaged an allocentric memory system based primarily in the medial occipito-temporal region. These findings suggest that visual path integration in humans over short distances can operate through a spatial working memory system engaging primarily the prefrontal cortex and that the differential configuration of memory systems recruited by task control networks may help explain individual biases in spatial learning strategies.
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影响因子：
19.9
作者：
Epstein, Russell A.
通讯作者：
Epstein, Russell A.
影响因子：
64.8
作者：
Epstein, R;Kanwisher, N
通讯作者：
Kanwisher, N
影响因子：
56.9
作者：
Fyhn, M;Molden, S;Moser, MB
通讯作者：
Moser, MB
影响因子：
3.2
作者：
Arnold, Aiden E. G. F.;Protzner, Andrea B.;Iaria, Giuseppe
通讯作者：
Iaria, Giuseppe
DOI：
10.1073/pnas.0901831106
发表时间：
2009-06-23
影响因子：
11.1
作者：
Deco, Gustavo;Jirsa, Viktor;Koetter, Rolf
通讯作者：
Koetter, Rolf