An update of the regulatory factors of sperm migration from the uterus into the oviduct by genetically manipulated mice
An update of the regulatory factors of sperm migration from the uterus into the oviduct by genetically manipulated mice
复制标题
基因改造小鼠精子从子宫迁移至输卵管调控因素的更新
DOI：
10.1002/mrd.23180
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发表时间：
2019-08
影响因子：
2.5
通讯作者：
Chunling Shen
中科院分区：
文献类型：
--
作者：
Wenfeng Xiong;Zhugang Wang;Chunling Shen
哺乳动物的生殖过程包括精子发生(发生在睾丸)和受精(发生在女性生殖道)。受精是一个连续的、多步骤的和极其复杂的过程，通常包括精子在子宫内的存活，精子通过子宫输卵管连接处和输卵管的迁移，精子穿过卵丘细胞层和透明带，以及精子和卵子的融合。可能有一个复杂的分子机制来确保上述过程顺利运行。先前的研究已经通过体外受精实验发现了这些受精步骤的基本因素。然而，最近在老鼠身上进行基因破坏的方法表明，许多以前被描述为对受精重要的因素在基因敲除动物中基本上是可有可无的，一些以前未知的因素正在出现。因此，最近转基因动物的出现修订了受精的分子机制，特别是精子从子宫迁移到输卵管。在这篇综述中，我们只关注并更新通过UTJ进行精子迁移的必要基因，并描述我们对哺乳动物精子迁移基础的最新认识进展。
Mammalian reproductive processes involve spermatogenesis, which occurs in the testis, and fertilization, which takes place in the female genital tract. Fertilization is a successive, multistep, and extremely complicated event that usually includes sperm survival in the uterus, sperm migration through the uterotubal junction (UTJ) and the oviduct, sperm penetration through the cumulus cell layer and the zona pellucida, and sperm–egg fusion. There may be a complex molecular mechanism to ensure that the above processes run smoothly. Previous studies have discovered essential factors for these fertilization steps through in vitro fertilization experiments. However, recent gene disruption approaches in mice have revealed that many of the factors previously described as important for fertilization are largely dispensable in gene‐knockout animals, and some previously unknown factors are emerging. As a result, the molecular mechanisms of fertilization, especially sperm migration from the uterus into the oviduct, have recently been revised by the emergence of genetically modified animals. In this review, we only focus on and update the essential genes for sperm migration through the UTJ and describe recent advances in our knowledge of the basis of mammalian sperm migration.
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影响因子：
4
作者：
J. Schlondorff;C. Blobel
通讯作者：
J. Schlondorff;C. Blobel
进化上保守的基因：Tex37、Ccdc73、Prss55 和 Nxt2 对于小鼠的生育能力来说是可有可无的
影响因子：
4.6
作者：
Khan M;Jabeen N;Khan T;Hussain HMJ;Ali A;Khan R;Jiang L;Li T;Tao Q;Zhang X;Yin H;Yu C;Jiang X;Shi Q
通讯作者：
Shi Q
DOI：
10.1074/jbc.m202420200
发表时间：
2002-06
期刊：
The Journal of Biological Chemistry
影响因子：
--
作者：
Y. Ouyang;J. Crawley;C. Aston;K. Moore
通讯作者：
Y. Ouyang;J. Crawley;C. Aston;K. Moore
影响因子：
3.6
作者：
Han, Cecil;Choi, Eunyoung;Cho, Chunghee
通讯作者：
Cho, Chunghee
影响因子：
4.6
作者：
Endo S;Yoshitake H;Tsukamoto H;Matsuura H;Kato K;Sakuraba M;Takamori K;Fujiwara H;Takeda S;Araki Y
通讯作者：
Araki Y