The Impact of FTO Genetic Variants on Obesity and Its Metabolic Consequences is Dependent on Daily Macronutrient Intake.
The Impact of FTO Genetic Variants on Obesity and Its Metabolic Consequences is Dependent on Daily Macronutrient Intake.
复制标题
DOI：
10.3390/nu12113255
复制
发表时间：
2020-10-23
期刊：
影响因子：
5.9
通讯作者：
Kretowski A
中科院分区：
文献类型：
--
作者：
Czajkowski P;Adamska-Patruno E;Bauer W;Fiedorczuk J;Krasowska U;Moroz M;Gorska M;Kretowski A
许多研究已经确定了与肥胖及其代谢后果相关的各种脂肪量和肥胖相关（FTO）遗传变异；然而，饮食因素对这些关联的影响尚不清楚。本研究的目的是评估FTO单核苷酸多态性（snp）、每日宏量营养素摄入量和肥胖及其代谢后果之间的关系。从1549名波兰血统的高加索人（FTO snp基因分型为rs3751812、rs8044769、rs8050136和rs9939609）中选择819名受试者进行基因-饮食互作分析。进行人体测量，测定全身脂肪含量和分布、口服葡萄糖耐量试验（OGTT）时血糖和胰岛素浓度以及血脂。根据三天的食物记录分析常量营养素摄入量，并使用国际身体活动问卷（IPAQ-LF）评估每日身体活动水平。我们的研究表明，rs3751812 GG基因型携带者如果每日能量摄入的48%以上来自碳水化合物，其体重、身体质量指数（BMI）、总脂肪含量、臀围和腰围较低，肥胖相关指标较低；如果每日能量摄入的30%以下来自膳食脂肪，其皮下和内脏脂肪含量较低。在rs8050136 CC基因型携带者中也观察到类似的结果。我们没有注意到rs8044769基因型之间的肥胖标记有任何显著差异，但我们确实观察到饮食-基因关联的显著影响。如果每日来自碳水化合物的能量摄入低于48%，TT和CT基因型携带者的体重和BMI显著升高。此外，在TT基因型携带者中，如果总能量摄入的18%以上来自蛋白质，我们观察到空腹和OGTT试验期间血糖浓度升高。总之，我们的研究结果表明，每日大量营养素摄入可能会调节FTO基因snp对肥胖和肥胖相关代谢后果的影响。
Numerous studies have identified the various fat mass and obesity-associated (FTO) genetic variants associated with obesity and its metabolic consequences; however, the impact of dietary factors on these associations remains unclear. The aim of this study was to evaluate the association between FTO single nucleotide polymorphisms (SNPs), daily macronutrient intake, and obesity and its metabolic consequences. From 1549 Caucasian subjects of Polish origin, genotyped for the FTO SNPs (rs3751812, rs8044769, rs8050136, and rs9939609), 819 subjects were selected for gene–diet interaction analysis. Anthropometric measurements were performed and total body fat content and distribution, blood glucose and insulin concentration during oral glucose tolerance test (OGTT), and lipid profile were determined. Macronutrient intake was analyzed based on three-day food records, and daily physical activity levels were evaluated using the International Physical Activity Questionnaire Long Form (IPAQ-LF). Our study shows that carriers of the GG genotype of rs3751812 presented lower body weight, body mass index (BMI), total body fat content, and hip and waist circumference and presented lower obesity-related markers if more than 48% of daily energy intake was derived from carbohydrates and lower subcutaneous and visceral fat content when energy intake derived from dietary fat did not exceed 30%. Similar results were observed for rs8050136 CC genotype carriers. We did not notice any significant differences in obesity markers between genotypes of rs8044769, but we did observe a significant impact of diet-gene associations. Body weight and BMI were significantly higher in TT and CT genotype carriers if daily energy intake derived from carbohydrates was less than 48%. Moreover, in TT genotype carriers, we observed higher blood glucose concentration while fasting and during the OGTT test if more than 18% of total energy intake was derived from proteins. In conclusion, our results indicate that daily macronutrient intake may modulate the impact of FTO genetic SNPs on obesity and obesity-related metabolic consequences.
登录
查看更多内容
影响因子：
158.5
作者：
Cecil, Joanne E.;Tavendale, Roger;Palmer, Colin N. A.
通讯作者：
Palmer, Colin N. A.
影响因子：
7.1
作者：
Bauer, Florianne;Elbers, Clara C.;van der Schouw, Yvonne T.
通讯作者：
van der Schouw, Yvonne T.
影响因子：
6.9
作者：
Ranzenhofer, Lisa M.;Mayer, Laurel E. S.;Rosenbaum, Michael
通讯作者：
Rosenbaum, Michael
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.
影响因子：
3.2
作者：
Hagstromer, Maria;Oja, Pekka;Sjostrom, Michael
通讯作者：
Sjostrom, Michael