Signatures of rapid plasticity in hippocampal CA1 representations during novel experiences.
Signatures of rapid plasticity in hippocampal CA1 representations during novel experiences.
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DOI：
10.1016/j.neuron.2022.03.026
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发表时间：
2022-06-15
期刊：
影响因子：
16.2
通讯作者：
Losonczy, Attila
中科院分区：
文献类型：
--
作者：
Priestley, James B.;Bowler, John C.;Rolotti, Sebi, V;Fusi, Stefano;Losonczy, Attila
海马中的神经元对感觉特征的特定组合表现出打击的选择，即使在完全新颖的经验中，它们也被认为可以予以保存，以使人迅速配置，以至于人口稀少在小鼠中，我们剖析了许多CA1神经元的位置田地的新颖性和经验的影响。 CA1中的有效学习率有利于田间形成的快速机制来编码新的经验。
Priestley等人结合了虚拟现实和两光子钙成像，在新体验中发现了小鼠海马中快速神经塑性机制的普遍性特征，强烈地调节了CA1中CA1中的神经元特征调节，这可以有效地编码新的记忆。
Neurons in the hippocampus exhibit striking selectivity for specific combinations of sensory features, forming representations which are thought to subserve episodic memory. Even during completely novel experiences, hippocampal “place cells” are rapidly configured such that the population sparsely encodes visited locations, stabilizing within minutes of the first exposure to a new environment. What mechanisms enable this fast encoding of experience? Using virtual reality and neural population recordings in mice, we dissected the effects of novelty and experience on the dynamics of place field formation. Place fields of many CA1 neurons shift locations and modulate the amplitude of their activity immediately after place field formation, rapid changes predicted by behavioral time scale synaptic plasticity. These correlates were particularly enriched during exploration of a novel context and decayed with experience. Our data suggest that novelty modulates the effective learning rate in CA1, favoring rapid mechanisms of field formation to encode new experience. Combining virtual reality and two-photon calcium imaging, Priestley et al find pervasive signatures of rapid neural plasticity mechanisms in the mouse hippocampus during new experiences. Their study highlights a strong regulation of neural feature tuning in CA1 by novelty, which could contribute to efficiently encoding new memories.
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影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
CA1 和 CA3 中不同位置的细胞动力学编码新环境中的体验。
影响因子：
16.6
作者：
Dong C;Madar AD;Sheffield MEJ
通讯作者：
Sheffield MEJ
DOI：
10.1073/pnas.2018422118
发表时间：
2021-12-21
影响因子：
11.1
作者：
Benna, Marcus K.;Fusi, Stefano
通讯作者：
Fusi, Stefano
影响因子：
16.6
作者：
Bocchio, Marco;Gouny, Claire;Cossart, Rosa
通讯作者：
Cossart, Rosa
影响因子：
64.8
作者：
Geiller, Tristan;Sadeh, Sadra;Losonczy, Attila
通讯作者：
Losonczy, Attila