Effect of race/ethnicity on hypertension risk subsequent to gestational diabetes mellitus.
Effect of race/ethnicity on hypertension risk subsequent to gestational diabetes mellitus.
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DOI：
10.1016/j.amjcard.2014.01.411
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发表时间：
2014-04-15
影响因子：
2.8
通讯作者：
Thadhani, Ravi
中科院分区：
文献类型：
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作者：
Bentley-Lewis, Rhonda;Powe, Camille;Ankers, Elizabeth;Wenger, Julia;Ecker, Jeffiey;Thadhani, Ravi
与非西班牙裔白人相比，不同种族/民族的人群中妊娠期糖尿病（GDM）患病率更高。虽然种族已被证明可以改变产后妇女的其他心血管疾病危险因素，但种族/民族在GDM和随后的高血压中的作用尚未得到检验。本研究的目的是通过对1998-2007年在马萨诸塞州总医院分娩的妇女进行回顾性分析，评估种族/民族对GDM和随后的高血压的影响。多变量分析用于确定GDM与1)种族/民族之间的关系；2)高血压;3)与高血压和种族/民族的相互作用。从分娩之日起，这些女性被随访了平均3.8年。在我们的4,010名女性人群中，GDM在非白人参与者中更为常见（p < 0.0001）。在调整了年龄、种族、胎次、妊娠早期收缩压、BMI、孕妇妊娠期体重增加和先兆子痫后，GDM也与分娩后高血压相关（HR 1.75, 95% CI 1.28-2.37; p = 0.0004）。此外，在种族分层的多变量分析中，西班牙裔（HR 3.25, 95% CI 1.85-5.72; p < 0.0001）和白人（1.68,95% CI 1.10-2.57; p = 0.02）患有GDM的女性与非GDM的种族/民族特异性女性相比，高血压风险更高。总之，与白人女性相比，西班牙裔女性患高血压的风险更高。患有GDM的西班牙裔和白人女性患高血压的风险高于没有GDM的女性。由于目前的研究在黑人和亚洲女性GDM患者中检测效果的能力有限，因此需要进一步的研究来阐明在这些年轻女性中加强高血压风险监测的必要性。
Gestational diabetes mellitus (GDM) prevalence is higher among racially/ethnically diverse groups compared to non-Hispanic white populations. While race has been shown to modify other cardiovascular disease risk factors in postpartum women, the role of race/ethnicity on GDM and subsequent hypertension has yet to be examined. The aim of this study was to evaluate the impact of race/ethnicity in relation to GDM and subsequent hypertension in a retrospective analysis of women who delivered at Massachusetts General Hospital from 1998–2007. Multivariate analyses were used to determine the associations between GDM and 1) race/ethnicity; 2) hypertension; and 3) the interaction with hypertension and race/ethnicity. Women were followed for a median of 3.8 years from the date of delivery. In our population of 4,010 women, GDM was more common among non-white participants (p < 0.0001). GDM was also associated with hypertension subsequent to delivery after adjusting for age, race, parity, first-trimester systolic blood pressure, BMI, maternal gestational weight gain, and preeclampsia (HR 1.75, 95% CI 1.28–2.37; p = 0.0004). Moreover, Hispanic (HR 3.25, 95% CI 1.85–5.72; p < 0.0001) and white (1.68, 95% CI 1.10–2.57; p = 0.02) women with GDM had greater hypertension risk relative to their race/ethnicity-specific counterparts without GDM in race-stratified multivariable analyses. In conclusion, Hispanic women compared to white women have an increased risk of hypertension. Hispanic and white women with GDM are at a greater risk for hypertension compared to those without GDM. Because the current study may have had limited power to detect effects among black and Asian women with GDM, further research is warranted to elucidate the need for enhanced hypertension risk surveillance among these young women.
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影响因子：
12.7
作者：
Thorpe, LE;Berger, D;Frieden, TR
通讯作者：
Frieden, TR
影响因子：
16.2
作者：
Dabelea, D;Snell-Bergeon, JK;McDuffie, RS
通讯作者：
McDuffie, RS
影响因子：
2.8
作者：
Gong, Jian;Savitz, David A.;Engel, Stephanie M.
通讯作者：
Engel, Stephanie M.
DOI：
10.1161/circoutcomes.113.000155
发表时间：
2014-01
期刊：
Circulation. Cardiovascular quality and outcomes
影响因子：
--
作者：
Sampson UK;Edwards TL;Jahangir E;Munro H;Wariboko M;Wassef MG;Fazio S;Mensah GA;Kabagambe EK;Blot WJ;Lipworth L
通讯作者：
Lipworth L
影响因子：
16.2
作者：
Shah BR;Retnakaran R;Booth GL
通讯作者：
Booth GL