Comorbidities in a Nationwide, Heterogenous Population of Veterans with Interstitial Cystitis/Bladder Pain Syndrome.
Comorbidities in a Nationwide, Heterogenous Population of Veterans with Interstitial Cystitis/Bladder Pain Syndrome.
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DOI：
10.1016/j.urology.2021.04.015
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发表时间：
2021-10
期刊：
影响因子：
2.1
通讯作者：
Anger JT
中科院分区：
文献类型：
--
作者：
Laden BF;Bresee C;De Hoedt A;Dallas KB;Scharfenberg A;Saxena R;Senechal JF;Barbour KE;Kim J;Freedland SJ;Anger JT
使用比迄今为止大多数研究更具异质性的样本来检查全国范围内患有 IC/BPS 的男性和女性人群中合并症的患病率。利用退伍军人事务信息学和计算基础设施，我们随机抽取了有或没有 ICD-9/ICD-10 诊断为 IC/BPS 的男性和女性患者样本。使用 ICD-9 和 ICD-IO 代码确定是否存在合并症（NUAS [慢性疲劳综合征、纤维肌痛、肠易激综合征、偏头痛]、背痛、糖尿病和吸烟）和心理社会因素（酗酒、创伤后应激障碍、性创伤和抑郁症史）。评估这些变量与 IC/BPS 状态之间的关联，同时调整种族/民族、年龄和性别的潜在混杂影响。对 872 名 IC/BPS 患者（355 名 [41%] 男性，517 名 [59%] 女性）和 558 名非 IC/BPS 患者（291 名 [52%] 男性，267 名 [48%] 女性）的数据进行了分析。 IC/BPS 患者比非 IC/BPS 患者更有可能出现更多合并症（2.72+/-1.77 vs 1.73+/-1.30，P < 0.001），经历一种或多种 NUAS（慢性疲劳综合征、纤维肌痛、肠易激综合征和偏头痛）（45% [388/872] vs. 18%） [101/558]；P < 0.001），并且至少一种心理社会因素的患病率较高（61% [529/872] vs. 46% [256/558]；P < 0.001）。有和没有 IC/BPS 的患者之间合并症频率的差异在女性患者中更为明显。这些发现验证了之前在更多样化的人群中进行 IC/BPS 合并症研究的结果。
To examine the prevalence of comorbid conditions in a nationwide population of men and women with IC/BPS utilizing a more heterogeneous sample than most studies to date. Using the Veterans Affairs Informatics and Computing Infrastructure, we identified random samples of male and female patients with and without an ICD-9/ICD-10 diagnosis of IC/BPS. Presence of comorbidities (NUAS [chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, migraines], back pain, diabetes, and smoking) and psychosocial factors (alcohol abuse, post-traumatic stress disorder, sexual trauma, and history of depression) were determined using ICD-9 and ICD-IO codes. Associations between these variables and IC/BPS status were evaluated while adjusting for the potential confounding impact of race/ethnicity, age, and gender. Data was analyzed from 872 IC/BPS patients (355 [41%] men, 517 [59%] women) and 558 non-IC/BPS patients (291 [52%] men, 267 [48%] women). IC/BPS patients were more likely than non-IC/BPS patients to have a greater number of comorbidities (2.72+/−1.77 vs 1.73+/−1.30, P < 0.001), experience one or more NUAS (chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, and migraines) (45% [388/872] vs. 18% [101/558]; P < 0.001) and had a higher prevalence of at least one psychosocial factor (61 % [529/872] v. 46% [256/558]; P < 0.001). Differences in the frequencies of comorbidities between patients with and without IC/BPS were more pronounced in female patients. These findings validate the findings of previous comorbidity studies of IC/BPS in a more diverse population.
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影响因子：
23.4
作者：
Temml, Christian;Wehrberger, Clemens;Madersbacher, Stephan
通讯作者：
Madersbacher, Stephan
影响因子：
2
作者：
Keller, Joseph J.;Liu, Shih-Ping;Lin, Herng-Ching
通讯作者：
Lin, Herng-Ching
影响因子：
2
作者：
Chuang, Yao-Chi;Weng, Shih-Feng;Wu, Ming-Ping
通讯作者：
Wu, Ming-Ping
影响因子：
4.7
作者：
Vincent, Ann;Lahr, Brian D.;St Sauver, Jennifer
通讯作者：
St Sauver, Jennifer
影响因子：
2
作者：
McKernan LC;Walsh CG;Reynolds WS;Crofford LJ;Dmochowski RR;Williams DA
通讯作者：
Williams DA