Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients
Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients
复制标题
亚综合征抑郁症患者、首发抑郁症患者和缓解期抑郁症患者在基于努力的决策中存在动机缺陷
DOI：
10.1016/j.psychres.2014.08.056
复制
发表时间：
2014-12
影响因子：
11.3
通讯作者：
Xie Guang-rong
中科院分区：
文献类型：
--
作者：
Yang, X.H.;Huang, Jia;Zhu Cui-yong;Wang Ye-fei;Cheung,E.F.C.;Chan Raymond C.K.;Xie Guang-rong
快感缺乏是重度抑郁症（MDD）的标志性症状。初步研究结果表明，快感缺乏的特点是奖励预期和获得奖励的动机降低。然而，人们对抑郁症中基于奖励的决策知之甚少。我们测试了这样的假设：MDD 的快感缺乏可能反映了基于奖励的决策动机的特定损害，并且这种缺陷可能与抑郁症状的严重程度有关。在研究 1 中，有或没有抑郁症状的个体执行了改进版的努力支出奖励任务 (EEfRT)，这是一种成本/收益决策的行为测量。在研究 2 中，MDD 患者、缓解后的 MDD 患者和健康对照者被招募进行相同的程序。我们发现证据表明亚综合征抑郁症患者为获得奖励而付出努力的意愿降低。这种效应在重度抑郁症患者中被放大，但在抑郁症缓解的患者中消失。我们还发现，MDD 患者的预期快乐和完成快乐的减少预示着他们为获得奖励而付出努力的意愿会降低。对于患有亚综合征抑郁症的个体，这些损害与预期性快感缺乏相关，但与完成性快感缺乏相关。这些数据提供了新的证据，证明 MDD 中的动机缺陷与抑郁症的严重程度相关，并且可以通过自我报告的快感缺乏来预测。
Anhedonia is a hallmark symptom of major depressive disorder (MDD). Preliminary findings suggest that anhedonia is characterized by reduced reward anticipation and motivation of obtaining reward. However, relatively little is known about reward-based decision-making in depression. We tested the hypothesis that anhedonia in MDD may reflect specific impairments in motivation on reward-based decision-making and the deficits might be associated with depressive symptoms severity. In study 1, individuals with and without depressive symptoms performed the modified version of the Effort Expenditure for Rewards Task (EEfRT), a behavioral measure of cost/benefit decision-making. In study 2, MDD patients, remitted MDD patients and healthy controls were recruited for the same procedures. We found evidence for decreased willingness to make effort for rewards among individuals with subsyndromal depression; the effect was amplified in MDD patients, but dissipated in patients with remitted depression. We also found that reduced anticipatory and consummatory pleasure predicted decreased willingness to expend efforts to obtain rewards in MDD patients. For individuals with subsyndromal depression, the impairments were correlated with anticipatory anhedonia but not consummatory anhedonia. These data offer novel evidence that motivational deficits in MDD are correlated with depression severity and predicted by self-reported anhedonia.
登录
查看更多内容
影响因子：
1.9
作者：
Bardgett, Mark E.;Depenbrock, Melissa;Downs, Nathan;Points, Megan;Green, Leonard
通讯作者：
Green, Leonard
DOI：
10.1111/j.1749-6632.1989.tb53242.x
发表时间：
1989-12
影响因子：
5.2
作者：
B. Hoebel;L. Hernandez;D. Schwartz;G. P. Mark;G. Hunter
通讯作者：
B. Hoebel;L. Hernandez;D. Schwartz;G. P. Mark;G. Hunter
DOI：
10.1523/jneurosci.4387-11.2011
发表时间：
2011-11-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Wardle MC;Treadway MT;Mayo LM;Zald DH;de Wit H
通讯作者：
de Wit H
影响因子：
10.6
作者：
Pizzagalli, DA;Jahn, AL;O'Shea, JP
通讯作者：
O'Shea, JP
影响因子：
4.6
作者：
Treadway, Michael T.;Bossaller, Nicholas A.;Shelton, Richard C.;Zald, David H.
通讯作者：
Zald, David H.