Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia.
Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia.
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DOI：
10.1037/a0028813
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发表时间：
2012-08
影响因子：
4.6
通讯作者：
Zald, David H.
中科院分区：
文献类型：
--
作者：
Treadway, Michael T.;Bossaller, Nicholas A.;Shelton, Richard C.;Zald, David H.
快感缺失是重性抑郁障碍（MDD）的核心特征，但快感缺失症状的确切性质尚不清楚。虽然快感缺失传统上被认为是快乐体验的不足，但最近的证据表明，预期和动机的减少也可能是这种症状的核心特征。在这里，我们提供了来自MDD患者和健康对照的研究数据，使用奖励动机的翻译测量，奖励任务的努力支出（EEfRT或“努力”）。这项任务为受试者提供了一系列的试验，他们可以选择花费更多或更少的努力来赢得不同数量的金钱奖励。我们发现MDD患者比对照组更不愿意为奖励而付出努力。此外，我们观察到，患者不太能够有效地使用奖励的大小和概率的奖励信息来指导他们的选择行为。最后，在MDD患者组中，当前发作的持续时间是EEfRT任务表现的显著负预测因子。这些发现提供了新的理论模型支持，提出在MDD的快感缺失可能反映了特定的动机和奖励为基础的决策障碍。
Anhedonia is a core feature of major depressive disorder (MDD), but the precise nature of anhedonic symptoms is unknown. While anhedonia has traditionally been viewed as a deficit in the experience of pleasure, more recent evidence suggests that reduced anticipation and motivation may also be a core feature of this symptom. Here, we provide data from a study in MDD patients and healthy controls using a translational measure of reward motivation, the Effort Expenditure for Rewards Task (EEfRT or “effort”). This task offers subjects a series of trials where they may choose to expend more or less effort for the opportunity to win varying amounts of monetary rewards. We found that MDD patients were less willing to expend effort for rewards than controls. Additionally, we observed that patients were less able to effectively use reward information about magnitude and probability of rewards to guide their choice behavior. Finally, within the MDD patient group, duration of the current episode was a significant negative predictor of EEfRT task performance. These findings offer novel support for theoretical models proposing that anhedonia in MDD may reflect specific impairments in motivation and reward-based decision-making.
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