Highly Aligned Poly(3,4-ethylene dioxythiophene) (PEDOT) Nano- and Microscale Fibers and Tubes.
Highly Aligned Poly(3,4-ethylene dioxythiophene) (PEDOT) Nano- and Microscale Fibers and Tubes.
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DOI：
10.1016/j.polymer.2012.10.057
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发表时间：
2013-01-24
期刊：
影响因子：
4.6
通讯作者：
Martin, David C.
中科院分区：
文献类型：
--
作者：
Feng, Zhang-Qi;Wu, Jinghang;Cho, Whirang;Leach, Michelle K.;Franz, Eric W.;Naim, Youssef I.;Gu, Zhong-Ze;Corey, Joseph M.;Martin, David C.
本研究报告了一种基于静电纺丝和氧化化学聚合的定向聚（3,4-乙烯二氧噻吩）（PEDOT）纤维和管材的简便制造方法。离散的 PEDOT 纳米纤维和微纤维以及纳米管和微米管很难快速且可重复地制造。我们采用聚丙交酯乙交酯 (PLGA) 聚合物，该聚合物负载有可聚合的 3,4-乙撑二氧噻吩 (EDOT) 单体，在静电纺丝过程中使用旋转玻璃芯轴创建对齐的纳米纤维组件。然后，EDOT 单体/PLGA 聚合物共混物通过暴露于氧化催化剂 (FeCl3) 进行聚合。 PEDOT 是通过在静电纺丝过程中将 FeCl3 溶液连续滴到玻璃棒上来聚合的。所得的 PEDOT 纤维具有导电性、排列整齐且离散。可以很容易地生产出几厘米长度的纤维束。将 PEDOT 皮/PLGA 芯纤维浸入氯仿中以除去 PLGA 和任何残留的 EDOT，从而形成中空的 PEDOT 管。这种方法可以轻松生成大面积的对齐 PEDOT 纤维/管。使用光学显微镜、电子显微镜、拉曼光谱、热重分析和直流电导率测量来测量对齐组件的结构和性能。我们还证明，对齐的 PEDOT 鞘/PLGA 核心纤维组件可用于在体外支持和指导背根神经节 (DRG) 神经元的延伸。
This study reports a facile method for the fabrication of aligned Poly(3,4-ethylene dioxythiophene) (PEDOT) fibers and tubes based on electrospinning and oxidative chemical polymerization. Discrete PEDOT nano- and microfibers and nano- and microtubes are difficult to fabricate quickly and reproducibly. We employed poly(lactide-co-glycolide) (PLGA) polymers that were loaded with polymerizable 3,4-ethylene dioxythiophene (EDOT) monomer to create aligned nanofiber assemblies using a rotating glass mandrel during electrospinning. The EDOT monomer/PLGA polymer blends were then polymerized by exposure to an oxidative catalyst (FeCl3). PEDOT was polymerized by continuously dripping a FeCl3 solution onto the glass rod during electrospinning. The resulting PEDOT fibers were conductive, aligned and discrete. Fiber bundles could be easily produced in lengths of several centimeters. The PEDOT sheath/PLGA core fibers were immersed in chloroform to remove the PLGA and any residual EDOT resulting in hollow PEDOT tubes. This approach made it possible to easily generate large areas of aligned PEDOT fibers/tubes. The structure and properties of the aligned assemblies were measured using optical microscopy, electron microscopy, Raman spectroscopy, thermal gravimetric analysis, and DC conductivity measurements. We also demonstrated that the aligned PEDOT sheath/PLGA core fiber assemblies could be used in supporting and directing the extension of dorsal root ganglia (DRG) neurons in vitro.
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