Hemagglutinin-neuraminidase glycoprotein as a determinant of pathogenicity in mumps virus hamster encephalitis: analysis of mutants selected with monoclonal antibodies
Hemagglutinin-neuraminidase glycoprotein as a determinant of pathogenicity in mumps virus hamster encephalitis: analysis of mutants selected with monoclonal antibodies
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血凝素神经氨酸酶糖蛋白作为腮腺炎病毒仓鼠脑炎致病性的决定因素：用单克隆抗体选择的突变体分析
DOI：
10.1128/jvi.53.1.67-74.1985
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发表时间：
1985
影响因子：
5.4
通讯作者：
E. Norrby
中科院分区：
文献类型：
--
作者：
A. Löve;R. Rydbeck;K. Kristensson;C. Orvell;E. Norrby
With the aid of monoclonal antibodies directed against a specific site on the hemagglutinin-neuraminidase surface glycoprotein, four mutants of the Kilham neurotropic strain of mumps virus were isolated. All four mutants had increased neuraminidase activity. Two mutants (M10 and M12) lost their hemagglutination capacity with human O erythrocytes but retained their ability to agglutinate guinea pig erythrocytes at 4 degrees C. A third mutant (M11) showed a change in the molecular weight of the hemagglutinin-neuraminidase glycoprotein. These three mutants (M10, M11, and M12) showed unaltered capacity to infect tissue cultures and to cause encephalitis in newborn hamsters. A fourth mutant (M13) retained its hemagglutination activity and capacity to infect Vero cell cultures but showed significantly lower neurovirulence in the suckling hamster brain than did the parental Kilham strain and the other three mutants. Both the number of infected neurons and the amount of infectious virus in the brain was reduced. On the other hand, there were no apparent differences in the occurrence of viral antigen in ependymal cells, indicating a selective change in affinity for neurons in the brain. These results suggest that certain changes in the hemagglutinin-neuraminidase glycoprotein may lead to an alteration of the neuropathogenicity of the Kilham strain of mumps virus.
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影响因子：
56.9
作者：
HOLLAND, J;SPINDLER, K;VANDEPOL, S
通讯作者：
VANDEPOL, S
用单克隆抗体选择和分析 N2 流感病毒神经氨酸酶抗原变异体。
影响因子：
3.7
作者：
Webster,RG;Hinshaw,VS;Laver,WG
通讯作者：
Laver,WG
影响因子：
3.8
作者：
LAFON, M;WIKTOR, TJ;MACFARLAN, RI
通讯作者：
MACFARLAN, RI
3 型呼肠孤病毒的血凝素变种改变了中枢神经系统的趋向性。
DOI：
10.1126/science.6301010
发表时间：
1983
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Spriggs,DR;Bronson,RT;Fields,BN
通讯作者：
Fields,BN
仙台病毒的 HN 糖蛋白：参与血凝和神经氨酸酶活性的位点分析。
影响因子：
3.7
作者：
Portner,A
通讯作者：
Portner,A