The role of children in household transmission of COVID-19: a systematic review and meta-analysis.
The role of children in household transmission of COVID-19: a systematic review and meta-analysis.
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儿童在Covid-19的家庭传播中的作用：系统的综述和荟萃分析。
DOI：
10.1016/j.ijid.2022.05.016
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发表时间：
2022-09
影响因子：
8.4
通讯作者：
Shi, Yuan
中科院分区：
文献类型：
--
作者：
Chen, Feifan;Tian, Yan;Zhang, Lixin;Shi, Yuan
探讨SARS冠状病毒2型在新变异流行期儿童中的家庭传播性。通过PubMed和Embase检索，将文献分为家庭继发发病率（SAR）的Meta分析和家庭儿科感染的病例分析两部分。共纳入95篇文章：48篇用于荟萃分析，47篇用于病例分析。儿童COVID-19仅占家庭传播的一小部分。儿童索引病例和接触者的总合并家庭SAR为0.20（95%置信区间[CI]：0.15-0.26）和0.24（95% CI：0.18-0.30）。儿童指数病例和接触者的家庭传播率均低于成人（相对危险度[RR] = 0.64，95% CI：0.50-0.81; RR = 0.74，95% CI：0.64-0.85）。年龄较小的儿童与年龄较大的儿童一样敏感（RR = 0.89，95%CI：0.72-1.10）。通过对不同变异体和不同时期的亚组分析，观察到儿童的家庭SAR增加（野生型：0.20; α：0.42; δ：0.35; Omicron：0.56），当新变异体占主导地位时，儿童和成人的家庭SAR无显著差异。虽然发现儿童在家庭传播中并不占主导地位，但随着新变种的出现，他们的SARS-CoV-2传播率似乎在上升。
To explore household transmissibility of SARS-CoV-2 in children in new-variants dominating periods. Through retrieval in PubMed and Embase, studies were included in two parts: meta-analysis of the household secondary attack rate (SAR) and case analysis of household pediatric infections. A total of 95 articles were included: 48 for meta-analysis and 47 for case analysis. Pediatric COVID-19 only comprised a minority of the household transmission. The total pooled household SAR of child index cases and contacts were 0.20 (95% confidence interval [CI]: 0.15–0.26) and 0.24 (95% CI: 0.18–0.30). Lower household transmissibility was reported in both child index cases and contacts than in adults (relative risk [RR] = 0.64, 95% CI: 0.50–0.81; RR = 0.74, 95% CI: 0.64–0.85). Younger children were as susceptible as the older children (RR = 0.89, 95% CI: 0.72–1.10). Through subgroup analyses of different variants and periods, increased household SAR was observed in children (Wild: 0.20; Alpha: 0.42; Delta: 0.35; Omicron: 0.56), and no significant difference was found in household SAR between children and adults when new variants dominated. Although children were found not to be dominant in the household transmission, their transmissibility of SARS-CoV-2 appeared to be on the rise as new variants emerged.
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DOI：
10.1126/science.abn8347
发表时间：
2022-03-25
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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影响因子：
4.2
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DOI：
10.1093/cid/ciab701
发表时间：
2022-05-30
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
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作者：
Cerami C;Popkin-Hall ZR;Rapp T;Tompkins K;Zhang H;Muller MS;Basham C;Whittelsey M;Chhetri SB;Smith J;Litel C;Lin KD;Churiwal M;Khan S;Rubinstein R;Claman F;Mollan K;Wohl D;Premkumar L;Powers KA;Juliano JJ;Lin FC;Lin JT
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DOI：
10.1016/s2352-4642(22)00027-x
发表时间：
2022-05
期刊：
The Lancet. Child & adolescent health
影响因子：
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作者：
Cloete J;Kruger A;Masha M;du Plessis NM;Mawela D;Tshukudu M;Manyane T;Komane L;Venter M;Jassat W;Goga A;Feucht U
通讯作者：
Feucht U
DOI：
10.1016/j.lanepe.2021.100252
发表时间：
2022-01
期刊：
The Lancet regional health. Europe
影响因子：
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作者：
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通讯作者：
COVID-19 Genomics UK (COG-UK Consortium)