Dynamic displacement of normal and detached semicircular canal cupula.
Dynamic displacement of normal and detached semicircular canal cupula.
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DOI：
10.1007/s10162-009-0174-y
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发表时间：
2009-12
影响因子：
2.4
通讯作者：
Highstein, Stephen M.
中科院分区：
文献类型：
--
作者：
Rabbitt, Richard D.;Breneman, Kathryn D.;King, Curtis;Yamauchi, Angela M.;Boyle, Richard;Highstein, Stephen M.
关键词：
在活体生理刺激下，同时测量半规管顶的动态位移和传入神经放电的调制。正常吸盘对阶跃刺激的适应时间常数平均为36 s，对应于正弦刺激的机械下角频率为0.0044 Hz。对于相当于40-200度/秒的头部角速度的刺激，杯的中心区域的位移增益平均为53 nm/度/秒。传入适应更迅速，比杯，表现出的放松过程，有助于显着的神经表示的角度头部运动的运河传入神经元的放电模式的存在。我们还研究了在过度的transcupular内淋巴压力下发生的壶腹机械脱离后壶腹和传入神经的时间常数的变化。分离的吸盘表现出急剧减少的适应时间常数（300 ms-3 s，n = 3），可以解释内淋巴迅速流过的吸盘的顶点。部分脱离的壶腹重新连接和正常的传入放电模式恢复5-7小时后脱离。这种再生过程可能与头部创伤后半规管功能的恢复有关。
The dynamic displacement of the semicircular canal cupula and modulation of afferent nerve discharge were measured simultaneously in response to physiological stimuli in vivo. The adaptation time constant(s) of normal cupulae in response to step stimuli averaged 36 s, corresponding to a mechanical lower corner frequency for sinusoidal stimuli of 0.0044 Hz. For stimuli equivalent to 40–200 deg/s of angular head velocity, the displacement gain of the central region of the cupula averaged 53 nm per deg/s. Afferents adapted more rapidly than the cupula, demonstrating the presence of a relaxation process that contributes significantly to the neural representation of angular head motions by the discharge patterns of canal afferent neurons. We also investigated changes in time constants of the cupula and afferents following detachment of the cupula at its apex—mechanical detachment that occurs in response to excessive transcupular endolymph pressure. Detached cupulae exhibited sharply reduced adaptation time constants (300 ms–3 s, n = 3) and can be explained by endolymph flowing rapidly over the apex of the cupula. Partially detached cupulae reattached and normal afferent discharge patterns were recovered 5–7 h following detachment. This regeneration process may have relevance to the recovery of semicircular canal function following head trauma.
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影响因子：
1.7
作者：
HILLMAN, DE
通讯作者：
HILLMAN, DE
影响因子：
3
作者：
DICKMAN, JD;REDER, PA;CORREIA, MJ
通讯作者：
CORREIA, MJ
DOI：
10.1073/pnas.0402824101
发表时间：
2004-11-02
影响因子：
11.1
作者：
Holstein, GR;Rabbitt, RD;Highstein, SM
通讯作者：
Highstein, SM
影响因子：
2.5
作者：
GOLDBERG, JM;FERNANDEZ, C
通讯作者：
FERNANDEZ, C
影响因子：
2.5
作者：
BAIRD, RA;DESMADRYL, G;GOLDBERG, JM
通讯作者：
GOLDBERG, JM