High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers.
High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers.
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DOI：
10.1002/mds.28960
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发表时间：
2022-05
影响因子：
8.6
通讯作者：
Chen, Honglei
中科院分区：
文献类型：
--
作者：
Yuan, Yaqun;Shrestha, Srishti;Luo, Zhehui;Li, Chenxi;Plassman, Brenda L.;Parks, Christine G.;Hofmann, Jonathan N.;Freeman, Laura E. Beane;Sandler, Dale P.;Chen, Honglei
做梦行为是快速眼动睡眠行为障碍的特征，是突触核病最特异的前驱标记物。农药暴露可能与做梦行为有关，但流行病学证据有限。在农业健康研究中，检查农民中高农药暴露事件与梦境实现行为的关系。我们对11,248名农民(年龄47±11岁)进行了多因素Logistic回归分析，以检验1993-1997年报告的高农药暴露事件与2013-2015年评估的梦境实施行为之间的关系。939名(8.3%)农民报告了梦境实现行为的历史。与未报告任何高农药暴露事件的农民相比，20年后举报的农民更有可能支持梦幻行为(优势比=1.75(95%可信区间：1.49~2.05))。当事后用肥皂和水清洗的时间延迟较长时(等待6小时为2.63(1.62-4.27)，30分钟内清洗为1.71(1.36-2.15))，当接触到呼吸道或消化道时(2.04(1.62-2.57)对1.58(1.29-1.93))，这种相关性似乎更强。在对所涉及的特定杀虫剂的分析中，我们发现两种有机氯杀虫剂(滴滴涕和林丹)、四种有机磷杀虫剂(甲拌磷、乙丙磷、特丁膦和对硫磷)、两种除草剂(甲草胺和百草枯)以及杀菌剂呈正相关。这项研究首次提供了流行病学证据，表明高农药暴露可能与梦境行为的更高风险有关。
Dream enacting behavior is a characteristic feature of rapid eye movement sleep behavior disorder, the most specific prodromal marker of synucleinopathies. Pesticide exposure may be associated with dream enacting behaviors, but epidemiological evidence is limited. To examine high pesticide exposure events in relation to dream enacting behaviors among farmers in the Agricultural Health Study. We conducted multivariable logistic regression analyses to examine high pesticide exposure events reported in 1993–1997 in relation to dream enacting behaviors assessed in 2013–2015 among 11,248 farmers (age 47±11 years). A history of dream enacting behaviors was reported by 939 (8.3%) farmers. Compared with farmers who did not report any high pesticide exposure event, those who reported were more likely to endorse dream enacting behaviors two decades later (odds ratio =1.75 (95% confidence interval: 1.49–2.05)). The association appeared stronger when there was a long delay in washing with soap and water after the event (2.63 (1.62–4.27) for waiting >6 hours vs. 1.71 (1.36–2.15) for washing within 30 minutes), and when the exposure involved the respiratory or digestive tract (2.04 (1.62–2.57) vs. 1.58 (1.29–1.93) for dermal contact only). In the analyses of specific pesticides involved, we found positive associations with two organochlorine insecticides (DDT and lindane), four organophosphate insecticides (phorate, ethoprop, terbufos, and parathion), two herbicides (alachlor and paraquat), and fungicides as a group. This study provides the first epidemiological evidence that high pesticide exposures may be associated with a higher risk of dream enacting behaviors.
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影响因子：
3.7
作者：
Shrestha S;Kamel F;Umbach DM;Beane Freeman LE;Koutros S;Alavanja M;Sandler DP;Chen H
通讯作者：
Chen H
影响因子：
8.6
作者：
Mahlknecht, Philipp;Seppi, Klaus;Hoegl, Birgit
通讯作者：
Hoegl, Birgit
农药接触和帕金森病风险：基于家庭的病例对照研究。
影响因子：
2.6
作者：
Hancock, Dana B.;Martin, Eden R.;Mayhew, Gregory M.;Stajich, Jeffrey M.;Jewett, Rita;Stacy, Mark A.;Scott, Burton L.;Vance, Jeffery M.;Scott, William K.
通讯作者：
Scott, William K.
影响因子：
5.6
作者：
Haba-Rubio, Jose;Frauscher, Birgit;Heinzer, Raphael
通讯作者：
Heinzer, Raphael
影响因子：
9.9
作者：
Postuma, R. B.;Montplaisir, J. Y.;Wolfson, C.
通讯作者：
Wolfson, C.