Correlation between MMP2 expression in lung cancer tissues and clinical parameters: a retrospective clinical analysis.
Correlation between MMP2 expression in lung cancer tissues and clinical parameters: a retrospective clinical analysis.
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DOI：
10.1186/s12890-020-01317-1
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发表时间：
2020-10-28
影响因子：
3.1
通讯作者：
Jiang Q
中科院分区：
文献类型：
--
作者：
Han L;Sheng B;Zeng Q;Yao W;Jiang Q
基质金属蛋白酶2（MMP 2）与恶性肿瘤的发生有关，本研究旨在探讨MMP 2在肺癌组织中的表达与肺癌临床参数的相关性。采用免疫组化法检测MMP 2在肺癌组织及癌旁组织中的表达。采用Kaplan-Meier曲线和多元回归分析MMP 2表达与肺癌临床参数的相关性。MMP 2在肺癌组织中的表达高于癌旁组织（p = 0.002）。MMP-2的升高与低分化（p = 0.022）、肿瘤大小（p = 0.032）、淋巴结转移（p < 0.001）、晚期（p = 0.002）相关。MMP 2高表达患者的术后生存时间短于MMP 2低表达患者（p = 0.001）。MMP 2高表达（p = 0.006）和晚期（p = 0.003）是肺癌患者生存的独立预后指标。MMP-2的表达与肺癌的恶性生物学行为密切相关，可能成为肺癌诊断和预后的一个潜在生物学指标。
Matrix metalloproteinase 2 (MMP2) has been found to be related to malignant tumors; the aim of this study was to investigate the correlation between MMP2 expression in lung cancer tissues and clinical parameters of lung cancer. The expression of MMP2 in lung cancer tissues and in adjacent non-malignant tissues was tested by immunohistochemistry. The correlation between the expression of MMP2 and clinical parameters of lung cancer was analyzed by Kaplan-Meier curve and multiple regression analysis. The expression of MMP2 was higher in lung cancer tissues than that in adjacent non-malignant tissues (p = 0.002). Increased MMP2 was associated with low differentiation (p = 0.022), tumor size (p = 0.032), lymph node metastasis (p < 0.001), advanced stage (p = 0.002). The post-surgical survival time in patients with high MMP2 expression was shorter than that in patients with low MMP2 expression (p = 0.001). High expression of MMP2 (p = 0.006) and advanced stage (p = 0.003) were independent prognostic indicators for survival of lung cancer patients. Increased MMP2 correlates with malignant biological behavior of lung cancer and it could be a potential biomarker for diagnosis and prognosis of the disease.
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