The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection.
The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection.
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DOI：
10.1007/s00436-010-1794-1
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发表时间：
2010-05
影响因子：
2
通讯作者：
Jelicks LA
中科院分区：
文献类型：
--
作者：
de Souza AP;Sieberg R;Li H;Cahill HR;Zhao D;Araújo-Jorge TC;Tanowitz HB;Jelicks LA
克氏锥虫感染引起人类和动物胃肠道（GI）的巨大综合征。在本研究中，我们采用磁共振成像非侵入性监测补硒对T。克氏病毒感染的小鼠CD 1小鼠感染T. cruzi（巴西株）表现出与我们最近在感染的C57 B1/6小鼠中报道的相似的肠扩张。平均肠腔直径增加了65%，在饮用水中补充2 ppm硒的小鼠中，增加减少到29%。当在食物中补充3 ppm硒时，管腔直径也显著减小，尽管感染的小鼠和补充感染的小鼠之间的差异较小。与正常未补充食物喂养的感染小鼠相比，用富硒食物喂养的感染小鼠的肠蠕动增加，并且与未感染小鼠的肠蠕动没有显着差异。我们认为Se可用于调节T引起的肠道紊乱所涉及的炎症、免疫和/或抗氧化反应。克氏感染
Infection with Trypanosoma cruzi causes mega-syndromes of the gastrointestinal (GI) tract in humans and animals. In the present study, we employed magnetic resonance imaging to non-invasively monitor the effect of selenium supplementation on alterations in the GI tract of T. cruzi-infected mice. CD1 mice infected with T. cruzi (Brazil strain) exhibited dilatation of the intestines similar to that we recently reported in infected C57Bl/6 mice. The average intestine lumen diameter increased by 65% and the increase was reduced to 29% in mice supplemented with 2 ppm selenium in the drinking water. When supplemented with 3 ppm selenium in chow the lumen diameter was also significantly reduced although the difference between the infected and infected supplemented mice was smaller. Intestinal motility in infected mice fed with selenium-enriched chow was increased compared with infected mice fed with normal unsupplemented chow and was not significantly different from intestinal motility in uninfected mice. We suggest that Se may be used to modulate the inflammatory, immunological, and/or antioxidant responses involved in intestinal disturbances caused by T. cruzi infection.
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