Dietary patterns and risk of developing knee osteoarthritis: data from the osteoarthritis initiative.
Dietary patterns and risk of developing knee osteoarthritis: data from the osteoarthritis initiative.
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DOI：
10.1016/j.joca.2021.02.571
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发表时间：
2021-06
影响因子：
7
通讯作者：
Lu B
中科院分区：
文献类型：
--
作者：
Xu C;Liu T;Driban JB;McAlindon T;Eaton CB;Lu B
一些研究已经检查了饮食因素与膝关节骨关节炎（OA）风险之间的关联。我们的目的是研究主要饮食模式与膝关节骨性关节炎发生风险的前瞻性关联。我们随访了骨关节炎倡议（OAI）的2,842名参与者，年龄在45至79岁之间，基线时至少有一个膝关节没有放射学膝关节OA，随访时间长达72个月。我们将随访访视期间膝关节OA发生率定义为Kellgren和Lawrence分级≥ 2。采用主成分分析，西方和谨慎的饮食模式。采用考克斯比例风险模型评估饮食模式与膝关节OA发病率之间的关系。在研究参与者中，385例（418例膝关节）在72个月内发生膝关节OA。遵循西方饮食模式与膝关节OA风险增加相关（HR四分位数4 vs 1 = 1.69，95% CI：1.13至2.52，p趋势：0.03），而遵守谨慎模式与膝关节OA风险降低相关（HR四分位数4 vs 1 = 0.70，95% CI：0.50 - 0.98，p趋势：0.05）。观察到的相关性在额外调整体重指数（BMI）后减弱。观察到的相关性通过BMI介导约30%。遵循西方饮食与膝关节OA风险增加相关，而遵循谨慎的饮食模式与膝关节OA风险降低相关。这些关联部分通过BMI介导。
Some studies have examined the association between dietary factors and risk of knee osteoarthritis (OA). We aimed to examine the prospective association of major dietary patterns with the risk of developing knee OA. We followed 2,842 participants in Osteoarthritis Initiative (OAI) aged 45 to 79 years and with at least one knee free from radiographic knee OA at baseline for up to 72 months. We defined knee OA incidence as Kellgren and Lawrence grade ≥ 2 during follow-up visits. Using principal component analysis, Western and prudent dietary patterns were derived. Cox proportional hazards models were used to assess the association between dietary patterns and incident knee OA. Among study participants, 385 (418 knees) developed knee OA within 72 months. Following a Western dietary pattern was associated with an increased risk of knee OA (HR quartile 4 vs 1 = 1.69, 95% CI: 1.13 to 2.52, p trend: 0.03), while adherence to the prudent pattern was associated with a reduced risk of knee OA (HR quartile 4 vs 1 = 0.70, 95% CI: 0.50 to 0.98, p trend: 0.05). The observed associations attenuated after additionally adjusting for body mass index (BMI). The observed associations were mediated through BMI by approximately 30%. Following a Western diet was associated with increased risk of knee OA, whereas following a prudent pattern was associated with a reduced risk of knee OA. The associations were partially mediated through BMI.
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DOI：
10.1111/obr.12173
发表时间：
2014-07
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Bliddal H;Leeds AR;Christensen R
通讯作者：
Christensen R
影响因子：
5.9
作者：
Misra, Devyani;Booth, Sarah L.;Tolstykh, Irina;Felson, David T.;Nevitt, Michael C.;Lewis, Cora E.;Torner, James;Neogi, Tuhina
通讯作者：
Neogi, Tuhina
影响因子：
3.6
作者：
Biesbroek, Sander;Kneepkens, Mirjam C.;Boer, Jolanda M. A.
通讯作者：
Boer, Jolanda M. A.
影响因子：
7.1
作者：
Chandler, Paulette D.;Balasubramanian, Raji;Rexrode, Kathryn M.
通讯作者：
Rexrode, Kathryn M.
影响因子：
4.7
作者：
Joseph, Gabby B.;McCulloch, Charles E.;Link, Thomas M.
通讯作者：
Link, Thomas M.