The role of Bisphenol A in shaping the brain, epigenome and behavior.
The role of Bisphenol A in shaping the brain, epigenome and behavior.
复制标题
DOI：
10.1016/j.yhbeh.2010.10.001
复制
发表时间：
2011-03
影响因子：
3.5
通讯作者：
Connelly, Jessica J.
中科院分区：
文献类型：
--
作者：
Wolstenholme, Jennifer T.;Rissman, Emilie F.;Connelly, Jessica J.
双酚A（BPA）是一种异种雌激素，于1891年首次合成。它的雌激素特性在1930年被发现，不久之后，化学家发现它在环氧树脂生产中的用途。自20世纪50年代以来，BPA已被用作聚碳酸酯塑料、聚苯乙烯树脂和牙科密封剂的合成单体。每年大约产生65亿磅BPA，它是主要的雌激素化合物，渗入附近的水和食物供应。在95%的人类尿液样本中检测到BPA，这表明环境暴露是广泛的。此外，BPA会影响生殖组织和大脑。因此，许多研究都集中在BPA对胚胎发育的影响上。FDA最近的更新（2010年1月）指出“双酚A对胎儿、婴儿和幼儿的大脑、行为和前列腺的潜在影响令人担忧”。鉴于这种担忧，我们对BPA对大脑和行为的作用进行了最新审查。我们开始讨论BPA作为内分泌活性化合物和改变DNA甲基化的试剂的作用。接下来，我们回顾了报道BPA对大脑和行为影响的出版物。最后，我们对这些数据的解释和未来研究方向的建议。
Bisphenol A (BPA) is a xenoestrogen that was first synthesized in 1891. Its estrogenic properties were discovered in 1930, and shortly after that chemists identified its usefulness in the production of epoxy resins. Since the 1950s BPA has been used as a synthetic monomer in the manufacturing of polycarbonate plastic, polystyrene resins, and dental sealants. Roughly 6.5 billion pounds of BPA are produced each year and it is the major estrogenic compound that leaches into nearby water and food supplies. BPA has been detected in 95% of human urine samples, which indicates that environmental exposure is widespread. Moreover, BPA affects reproductive tissues and the brain. Thus many studies have focused on the effects of BPA during embryonic development. The most recent FDA update (Administration January 2010) points to “some concern about the potential effects of Bisphenol A on the brain, behavior, and prostate gland in fetuses, infants, and young children.” In light of this concern, we present an updated review of BPA’s action on the brain and behavior. We begin with a discussion of BPA’s role as both an endocrine active compound and an agent that alters DNA methylation. Next, we review publications that have reported effects of BPA on brain and behavior. We end with our interpretation of these data and suggestions for future research directions.
登录
查看更多内容
DOI：
10.1073/pnas.0610410104
发表时间：
2007-04-03
影响因子：
11.1
作者：
Crews, David;Gore, Andrea C.;Skinner, Michael K.
通讯作者：
Skinner, Michael K.
影响因子：
7.4
作者：
Arnold, Arthur P.;Chen, Xuqi
通讯作者：
Chen, Xuqi
在小鼠表观遗传敏感等位基因上DNA甲基化的动态重编程。
影响因子：
4.5
作者：
Blewitt ME;Vickaryous NK;Paldi A;Koseki H;Whitelaw E
通讯作者：
Whitelaw E
影响因子：
10.4
作者：
Calafat AM;Kuklenyik Z;Reidy JA;Caudill SP;Ekong J;Needham LL
通讯作者：
Needham LL
影响因子：
25
作者：
Carruth, LL;Reisert, I;Arnold, AP
通讯作者：
Arnold, AP