Alteration of intestinal microbiota in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent.
Alteration of intestinal microbiota in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent.
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DOI：
10.1371/journal.pone.0075008
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Nakane A
中科院分区：
文献类型：
--
作者：
Asano K;Yoshimura S;Nakane A
从鲑鱼鼻软骨中提取的蛋白多糖（PG）具有预防疾病的潜力。每日口服PG可减弱实验小鼠模型中的全身炎症反应。在这项研究中，我们应用非培养方法来研究PG给药小鼠肠道微生物群组成的变化。结果表明，PG给药后，小肠和大肠中杆菌的种群水平增加。另一方面，大肠中梭菌的群体水平下降。能够发酵脂肪酸并产生短链脂肪酸的细菌比例在小肠中增加，在大肠中减少。重要的是，在PG给药小鼠中，益生菌乳酸杆菌和表现出免疫调节作用的细菌的群体水平增加。此外，PG给药后，几种疾病相关细菌减少。这些结果提供了一个特定的角色参与宿主免疫调节的PG的理解，并支持我们的假设，每日口服PG改善肠道微生物群落组成的整体平衡。
Proteoglycan (PG) extracted from salmon nasal cartilage has potential to be a prophylactic agent. Daily oral administration of the PG attenuates systemic inflammatory response in the experimental mouse models. In this study, we applied the culture-independent approach to investigate an alteration of intestinal microbiota composition in PG-administered mice. The results indicated that the population level of bacilli increased in the small and large intestine upon PG administration. On the other hand, the population level of clostridia decreased in the large intestine. The proportion of bacteria that are able to ferment saccharides and produce short-chain fatty acids increased in the small intestine and decreased in the large intestine. Importantly, population level of probiotic lactobacilli and bacteria exhibiting the immunomodulatory effect increased in the PG-administered mice. In addition, several disease-associated bacteria decreased upon PG administration. These results provided an understanding of the specific role of PG involved in host immune modulation and supported our hypothesis that daily oral administration of PG improves the overall balance in composition of the intestinal microbial community.
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DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
4.6
作者：
Kverka, M.;Zakostelska, Z.;Tlaskalova-Hogenova, H.
通讯作者：
Tlaskalova-Hogenova, H.
DOI：
10.1099/ijs.0.015016-0
发表时间：
2010-07
影响因子：
2.8
作者：
Clavel T;Duck W;Charrier C;Wenning M;Elson C;Haller D
通讯作者：
Haller D
影响因子：
4.2
作者：
Li, Fei;Hullar, Meredith A. J.;Lampe, Johanna W.
通讯作者：
Lampe, Johanna W.
影响因子：
3.7
作者：
Andersson, Anders F.;Lindberg, Mathilda;Jakobsson, Hedvig;Backhed, Fredrik;Nyren, Pal;Engstrand, Lars
通讯作者：
Engstrand, Lars