Conserved organization of the human and murine T-cell receptor β-gene families
Conserved organization of the human and murine T-cell receptor β-gene families
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人类和鼠 T 细胞受体 β 基因家族的保守组织
作者：
E. Lai;P. Concannon;L. Hood
免疫反应的产生取决于造血细胞类型的相互作用，其中T细胞及其受体是至关重要的。T细胞受体是由二硫键连接的α和β链组成的异二聚体，每条链分为可变区（V）和恒定区（C）1 -4。β -链是由T细胞分化和进化过程中独立的可变（Vβ多样性（Dβ）和连接（Jβ）基因片段的重排所编码的。我们构建了一个包含40个Vβ基因片段和两个Cβp基因簇的人T细胞受体β -链家族的物理图谱。比较已发表的人和鼠Vβ基因片段的核苷酸序列，发现12个基因片段具有65%或更高的种间同源性。这些人和鼠Vβ基因片段同源物的相对顺序在染色体上也是沿着保守的，除了更广泛的人类基因复制，推测是由于对进化机制施加的约束使这些基因家族多样化或选择压力维持顺序。
Generation of an immune response depends on the interaction of haematopoietic cell types, among which T cells and their receptors are of central importance. The T-cell receptor is a heterodimer consisting of disulphide-linked α andβ -chains, each chain divided into variable (V) and constant (C) regions1–4. Theβ -chain is encoded by the rearrangement of separate variable ( Vβ diversity (Dβ) and joining (Jβ) gene segments during T-cell differenti- ment and evolution of the β-gene segments, we have constructed a physical map of the human T-cell receptor β -chain family containing 40 Vβ gene segments as well as both Cβp gene clusters. A comparison of the published nucleotide sequences of human and murine Vβ gene segments reveals 12 examples of gene segments sharing 65% or more interspecies homology. The relative order of these human and murine Vβ gene segment homologues is also conserved along the chromosome, apart from more extensive human gene duplication, presumably as a consequence of con-straints imposed on evolutionary mechanisms operating to diversify these gene families or of selective pressures operating to maintain order.
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小鼠 T 细胞受体 β 链基因家族的基因组结构。
DOI：
10.1073/pnas.84.11.3846
发表时间：
1987
影响因子：
11.1
作者：
Lai,E;Barth,RK;Hood,L
通讯作者：
Hood,L
影响因子：
56.9
作者：
R. Perlmutter;J. Kearney;S. P. Chang;L. Hood
通讯作者：
R. Perlmutter;J. Kearney;S. P. Chang;L. Hood
DOI：
10.1073/pnas.83.18.7018
发表时间：
1986-09-01
影响因子：
11.1
作者：
SINGER, PA;MCEVILLY, RJ;THEOFILOPOULOS, AN
通讯作者：
THEOFILOPOULOS, AN
影响因子：
4.4
作者：
James P. Allison;Bradley W. McIntyre;D. Bloch
通讯作者：
James P. Allison;Bradley W. McIntyre;D. Bloch
影响因子：
56.9
作者：
SCHROEDER, HW;HILLSON, JL;PERLMUTTER, RM
通讯作者：
PERLMUTTER, RM