The effects of endocrine-disrupting chemicals on ovarian- and ovulation-related fertility outcomes.
The effects of endocrine-disrupting chemicals on ovarian- and ovulation-related fertility outcomes.
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DOI：
10.1002/mrd.23652
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发表时间：
2022-12
影响因子：
2.5
通讯作者：
Hannon, Patrick R.
中科院分区：
文献类型：
--
作者：
Land, Katie L.;Miller, Frances G.;Fugate, Ava C.;Hannon, Patrick R.
暴露于内分泌干扰物(EDCs)是不可避免的，考虑到EDCs以卵巢为靶标的能力，这是一个公共卫生问题。然而，关于内分泌细胞对卵巢功能的影响，包括排卵过程，目前还存在着很大的差距。排卵缺陷是女性不孕的主要原因，而EDC暴露是导致不孕症流行的原因之一。因此，研究内分泌细胞对卵巢和排卵的影响是一个新兴的研究领域，也是本综述的重点。EDCs对配子发生、子宫功能、胚胎发育和生育的其他方面的影响没有讨论到与卵巢和排卵相关的生育问题。在此，总结了几种EDCs的流行病学和基础科学研究结果，包括邻苯二甲酸酯、双酚、全氟烷基和多氟烷基物质、阻燃剂、对羟基苯甲酸酯和三氯生。流行病学文献表明，暴露与生殖力受损和体外受精结局(卵子产量、妊娠率和新生儿减少)有关，而基础科学文献报道改变了卵巢卵泡和黄体的数量，改变了激素水平，并损害了排卵过程。未来的方向包括确定EDCs干扰排卵导致不孕不育的机制，特别是在女性中。
Exposure to endocrine‐disrupting chemicals (EDCs) is unavoidable, which represents a public health concern given the ability of EDCs to target the ovary. However, there is a large gap in the knowledge about the impact of EDCs on ovarian function, including the process of ovulation. Defects in ovulation are the leading cause of infertility in women, and EDC exposures are contributing to the prevalence of infertility. Thus, investigating the effects of EDCs on the ovary and ovulation is an emerging area for research and is the focus of this review. The effects of EDCs on gametogenesis, uterine function, embryonic development, and other aspects of fertility are not addressed to focus on ovarian‐ and ovulation‐related fertility issues. Herein, findings from epidemiological and basic science studies are summarized for several EDCs, including phthalates, bisphenols, per‐ and poly‐fluoroalkyl substances, flame retardants, parabens, and triclosan. Epidemiological literature suggests that exposure is associated with impaired fecundity and in vitro fertilization outcomes (decreased egg yield, pregnancies, and births), while basic science literature reports altered ovarian follicle and corpora lutea numbers, altered hormone levels, and impaired ovulatory processes. Future directions include identification of the mechanisms by which EDCs disrupt ovulation leading to infertility, especially in women.
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DOI：
10.1038/nrendo.2016.186
发表时间：
2017-03
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
Braun JM
通讯作者：
Braun JM
影响因子：
3.2
作者：
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影响因子：
11.8
作者：
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Wong LY
DOI：
10.1111/rda.13130
发表时间：
2018-04
期刊：
Reproduction in domestic animals = Zuchthygiene
影响因子：
--
作者：
Campen KA;Lavallee M;Combelles C
通讯作者：
Combelles C
影响因子：
2.1
作者：
Berni, M.;Gigante, P.;Basini, G.
通讯作者：
Basini, G.