The impact of bisphenol S on bovine granulosa and theca cells.
The impact of bisphenol S on bovine granulosa and theca cells.
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DOI：
10.1111/rda.13130
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Combelles C
中科院分区：
文献类型：
--
作者：
Campen KA;Lavallee M;Combelles C
双酚S（BPS）是一种内分泌干扰化学品，具有多种潜在的作用机制，包括作为雌激素受体激动剂。BPS越来越多地用于塑料和热接收器中，作为双酚A的替代品，由于对人类健康影响的担忧，双酚A已被淘汰。BPS改变哺乳动物雌性生殖功能的能力尚未得到广泛研究，尽管正常激素信号对雌性生殖的重要性。本研究的目的是研究BPS（在广泛的剂量范围内，包括非常低的剂量）如何影响牛的颗粒细胞和卵泡膜细胞类固醇激素的产生和细胞活力。当细胞在基础条件下暴露于100 µM BPS时，颗粒细胞雌二醇的产生被刺激，但当细胞被促卵泡激素（FSH）刺激时，BPS没有影响。此外，在基础或FSH刺激条件下，BPS对颗粒细胞孕酮产生或细胞活力没有影响。BPS不影响卵泡膜细胞雄烯二酮或孕酮的生产，或卵泡膜细胞的活力基础或促黄体激素刺激条件下。这项研究首次表明，BPS可能会改变牛颗粒细胞的雌二醇产生，尽管浓度不太可能与生理相关。BPS对牛卵母细胞和卵泡细胞其他功能的影响有待进一步研究。
Bisphenol S (BPS) is an endocrine disrupting chemical with multiple potential mechanisms of action, including as an estrogen receptor agonist. BPS is increasingly used in plastics and thermal receipts as a substitute for bisphenol A, which has been phased out due to concerns about human health implications. The ability of BPS to alter female reproductive function in mammals has not been widely studied, despite the importance of normal hormone signaling for female reproduction. The aim of this study was to investigate how BPS (in a wide range of doses, including very low doses) affects granulosa cell and theca cell steroid hormone production and cell viability in the bovine. Granulosa cell estradiol production was stimulated when cells were exposed to 100 µM BPS under basal conditions, but there was no effect of BPS when cells were stimulated with follicle stimulating hormone (FSH). Additionally, there was no effect of BPS on granulosa cell progesterone production or cell viability under basal or FSH-stimulated conditions. BPS did not affect theca cell androstenedione or progesterone production, or theca cell viability under basal or luteinizing hormone-stimulated conditions. This study suggests for the first time that BPS may alter estradiol production by bovine granulosa cells, albeit at a concentration that is unlikely to be physiologically relevant. Further studies are needed to determine the effects of BPS on the bovine oocyte and on other functions of follicular cells.
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