Thalamic structures and associated cognitive functions: Relations with age and aging.
Thalamic structures and associated cognitive functions: Relations with age and aging.
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DOI：
10.1016/j.neubiorev.2015.03.008
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发表时间：
2015-07
影响因子：
8.2
通讯作者：
Sullivan, Edith V.
中科院分区：
文献类型：
--
作者：
Fama, Rosemary;Sullivan, Edith V.
丘脑与其皮层、皮层下和小脑的连接，是支持认知功能网络的关键节点，已知认知功能在正常衰老过程中下降，包括记忆的组成过程和注意和信息处理的执行功能。丘脑的宏观结构、微观结构和神经连通性在整个成年人的一生中都会发生变化。结构和功能磁共振成像（MRI）和弥散张量成像（DTI）显示，区域丘脑体积缩小和微结构退化，前部区域通常比后部区域更受损。选择性丘脑核和突起的完整性随着年龄的增长而下降，特别是在丘脑额叶、丘脑顶叶和丘脑边缘网络。本文综述了年龄与衰老与丘脑及其相关神经网络的结构、功能和连通性之间的关系，并重点介绍了它们与注意力过程、信息处理速度、工作记忆和情景记忆之间的关系。
The thalamus, with its cortical, subcortical, and cerebellar connections, is a critical node in networks supporting cognitive functions known to decline in normal aging, including component processes of memory and executive functions of attention and information processing. The macrostructure, microstructure, and neural connectivity of the thalamus changes across the adult lifespan. Structural and functional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) have demonstrated, regional thalamic volume shrinkage and microstructural degradation, with anterior regions generally more compromised than posterior regions. The integrity of selective thalamic nuclei and projections decline with advancing age, particularly those in thalamofrontal, thalamoparietal, and thalamolimbic networks. This review presents studies that assess the relations between age and aging and the structure, function, and connectivity of the thalamus and associated neural networks and focuses on their relations with processes of attention, speed of information processing, and working and episodic memory.
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影响因子：
3.7
作者：
Johansen-Berg, H;Behrens, TEJ;Matthews, PM
通讯作者：
Matthews, PM
DOI：
10.1037/0278-7393.11.3.501
发表时间：
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