Genome structure and dynamics of the yeast pathogen Candida glabrata.
Genome structure and dynamics of the yeast pathogen Candida glabrata.
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DOI：
10.1111/1567-1364.12145
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发表时间：
2014-06
影响因子：
3.2
通讯作者：
Piškur J
中科院分区：
文献类型：
--
作者：
Ahmad KM;Kokošar J;Guo X;Gu Z;Ishchuk OP;Piškur J
光滑念珠菌（Candida glabrata）是念珠菌感染的第二大常见原因。然而，从系统发育的角度来看，C. glabrata更接近酿酒酵母而不是白色念珠菌。显然，这种酵母菌最近改变了它的生活方式，成为一种成功的机会致病菌。最近，几个C。glabrata姊妹种，其中临床和环境分离株，已对其基因组进行了表征。数百个C。光滑型临床分离物的基因组已经被鉴定。这些分离株显示出巨大的基因组可塑性。染色体的数目和大小变化很大，染色体内和染色体间的片段重复也经常发生。观察到的基因组改变可能会影响表型特性，从而有助于适应这种酵母在不同人类患者及其组织中发现的高度可变和恶劣的栖息地。致病性分离株的进一步基因组测序将提供一个有价值的工具，以了解基因组动力学背后的机制，并有助于阐明基因的毒力潜力。
The yeast pathogen Candida glabrata is the second most frequent cause of Candida infections. However, from the phylogenetic point of view, C. glabrata is much closer to Saccharomyces cerevisiae than to Candida albicans. Apparently, this yeast has relatively recently changed its life style and become a successful opportunistic pathogen. Recently, several C. glabrata sister species, among them clinical and environmental isolates, have had their genomes characterized. Also, hundreds of C. glabrata clinical isolates have been characterized for their genomes. These isolates display enormous genomic plasticity. The number and size of chromosomes vary drastically, as well as intra- and interchromosomal segmental duplications occur frequently. The observed genome alterations could affect phenotypic properties and thus help to adapt to the highly variable and harsh habitats this yeast finds in different human patients and their tissues. Further genome sequencing of pathogenic isolates will provide a valuable tool to understand the mechanisms behind genome dynamics and help to elucidate the genes contributing to the virulence potential.
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