Associations of 25-hydroxyvitamin D with fasting glucose, fasting insulin, dementia and depression in European elderly: the SENECA study.
Associations of 25-hydroxyvitamin D with fasting glucose, fasting insulin, dementia and depression in European elderly: the SENECA study.
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欧洲老年人中25-羟基维生素D与禁食葡萄糖，禁食胰岛素，痴呆症和抑郁症的关联：塞内卡研究。
DOI：
10.1007/s00394-012-0399-0
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发表时间：
2013-04
影响因子：
5
通讯作者：
de Groot LC
中科院分区：
文献类型：
--
作者：
Brouwer-Brolsma EM;Feskens EJ;Steegenga WT;de Groot LC
维生素D缺乏的经典后果是骨软化症，但最近对维生素D功能的了解表明，它可能在其他身体系统中也发挥作用。本研究的目的是检查25-羟基维生素D（25（OH）D）和葡萄糖代谢（n = 593），全球认知功能（n = 116）和抑郁症（n = 118）在欧洲老年人参与SENECA研究的标志物之间的关联。此外，我们还想探讨25（OH）D与抑郁症和整体认知能力的关系是否受空腹血糖（FPG）水平的影响。通过多元回归分析评估25（OH）D与FPG、空腹血浆胰岛素（FPI）和稳态模型评估胰岛素抵抗（HOMA-IR）（胰岛素抵抗的标志物）之间的横断面相关性。使用Poisson回归分析25（OH）D与整体认知功能（简易精神状态检查）和抑郁症（老年抑郁量表）的关系。观察到25（OH）D与FPG之间呈负相关（β-0.001），表明25（OH）D每增加10 nmol/L，FPG降低1%，但在对人口统计学因素、生活方式因素和钙摄入量进行全面调整后，该相关性无统计学意义（P = 0.07）。尽管在调整人口统计学和生活方式因素后，血清25（OH）D水平中等和高水平的参与者表现出抑郁评分较低的趋势，但RR和95%CI分别为：0.73（0.51-1.04）和0.76（0.52-1.11），这些发现没有统计学意义。观察到25（OH）D与抑郁和FPG呈负相关，但这种相关性无统计学意义。25（OH）D与FPI和HOMA-IR或整体认知功能无关。需要更多的研究来进一步探索维生素D在各种身体系统中的可能作用。
The classical consequence of vitamin D deficiency is osteomalacia, but recent insights into the function of vitamin D suggest that it may play a role in other body systems as well. The objective of this study was to examine the association between 25-hydroxyvitamin D (25(OH)D) and markers of glucose metabolism (n = 593), global cognitive functioning (n = 116) and depression (n = 118) in European elderly participating in the SENECA study. Moreover, we wanted to explore whether the observed associations of 25(OH)D with depression and global cognitive performance were mediated by fasting plasma glucose (FPG) levels. Cross-sectional associations between 25(OH)D and FPG, fasting plasma insulin (FPI) and homeostatic model assessment-insulin resistance (HOMA-IR), a marker of insulin resistance, were estimated from multiple regression analyses. Associations of 25(OH)D with global cognitive functioning (Mini Mental State Examination) and depression (Geriatric Depression Scale) were examined using Poisson regression. An inverse association was observed between 25(OH)D and FPG (β-0.001), indicating a 1 % decrease in FPG per 10 nmol/L increase in 25(OH)D, but after full adjustment for demographic factors, lifestyle factors and calcium intake, this association was not statistically significant (P = 0.07). Although participants with intermediate and high serum 25(OH)D levels showed a tendency towards a lower depression score after adjustment for demographic and lifestyle factors, RR and 95 % CI: 0.73 (0.51–1.04) and 0.76 (0.52–1.11), respectively, these findings were not statistically significant. An inverse association of 25(OH)D with depression and FPG was observed, but this association was not statistically significant. There was no association between 25(OH)D with FPI and HOMA-IR or with global cognitive functioning. More studies are needed to further explore the possible role of vitamin D in the various body systems.
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影响因子：
2.8
作者：
Alvarez JA;Ashraf A
通讯作者：
Ashraf A
影响因子：
9.9
作者：
Buell, J. S.;Dawson-Hughes, B.;Tucker, K. L.
通讯作者：
Tucker, K. L.
影响因子：
8.2
作者：
JARRETT, RJ;MURRELLS, TJ;HALL, T
通讯作者：
HALL, T
影响因子：
8.2
作者：
KALMIJN, S;FESKENS, EJM;KROMHOUT, D
通讯作者：
KROMHOUT, D
影响因子：
11
作者：
Lee, David M.;Tajar, Abdelouahid;Wu, Frederick C. W.
通讯作者：
Wu, Frederick C. W.