Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III.
Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III.
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DOI：
10.1186/1741-7015-11-187
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发表时间：
2013-08-27
期刊：
影响因子：
9.3
通讯作者：
Dai Q
中科院分区：
文献类型：
--
作者：
Deng X;Song Y;Manson JE;Signorello LB;Zhang SM;Shrubsole MJ;Ness RM;Seidner DL;Dai Q
镁在维生素D的合成和代谢中起着至关重要的作用，补充镁可显著逆转镁依赖性维生素D抵抗性佝偻病患者对维生素D治疗的抵抗。我们假设，膳食镁单独，特别是其与维生素D摄入量的相互作用，有助于血清25-羟基维生素D（25（OH）D）水平，血清25（OH）D和死亡风险之间的关联可能会被镁摄入量水平改变。我们利用2001年至2006年全国健康与营养调查（NHANES）（一项基于人群的横断面研究）和NHANES III队列（一项基于人群的队列研究）的数据对这些新假设进行了检验。血清25（OH）D用于确定维生素D状态。NHANES III队列的死亡率结果通过与国家死亡指数（NDI）的概率联系来确定。总镁、膳食镁或补充镁的高摄入量分别与维生素D缺乏和不足的风险显著降低独立相关。镁的摄入量与维生素D的摄入量在维生素D缺乏和不足的风险方面存在显着的相互作用。此外，总镁摄入量和维生素D不足之间的负相关主要出现在维生素D不足的高风险人群中。此外，血清25（OH）D与死亡率的相关性，特别是由于心血管疾病（CVD）和结直肠癌，通过镁摄入量进行了修改，并且逆相关性主要存在于镁摄入量高于中位数的人群中。我们的初步研究结果表明，镁摄入量单独或其与维生素D摄入量的相互作用可能有助于维生素D状态。血清25（OH）D和死亡风险之间的关联可能会被镁的摄入水平所改变。未来的研究，包括队列研究和临床试验，是必要的，以证实这一发现。
Magnesium plays an essential role in the synthesis and metabolism of vitamin D and magnesium supplementation substantially reversed the resistance to vitamin D treatment in patients with magnesium-dependent vitamin-D-resistant rickets. We hypothesized that dietary magnesium alone, particularly its interaction with vitamin D intake, contributes to serum 25-hydroxyvitamin D (25(OH)D) levels, and the associations between serum 25(OH)D and risk of mortality may be modified by magnesium intake level. We tested these novel hypotheses utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2001 to 2006, a population-based cross-sectional study, and the NHANES III cohort, a population-based cohort study. Serum 25(OH)D was used to define vitamin D status. Mortality outcomes in the NHANES III cohort were determined by using probabilistic linkage with the National Death Index (NDI). High intake of total, dietary or supplemental magnesium was independently associated with significantly reduced risks of vitamin D deficiency and insufficiency respectively. Intake of magnesium significantly interacted with intake of vitamin D in relation to risk of both vitamin D deficiency and insufficiency. Additionally, the inverse association between total magnesium intake and vitamin D insufficiency primarily appeared among populations at high risk of vitamin D insufficiency. Furthermore, the associations of serum 25(OH)D with mortality, particularly due to cardiovascular disease (CVD) and colorectal cancer, were modified by magnesium intake, and the inverse associations were primarily present among those with magnesium intake above the median. Our preliminary findings indicate it is possible that magnesium intake alone or its interaction with vitamin D intake may contribute to vitamin D status. The associations between serum 25(OH)D and risk of mortality may be modified by the intake level of magnesium. Future studies, including cohort studies and clinical trials, are necessary to confirm the findings.
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影响因子：
4
作者：
Gutierrez, O. M.;Farwell, W. R.;Kermah, D.;Taylor, E. N.
通讯作者：
Taylor, E. N.
影响因子：
3.3
作者：
Lee, Jung Eun;Li, Haojie;Ma, Jing
通讯作者：
Ma, Jing
影响因子：
--
作者：
Melamed, Michal L.;Michos, Erin D.;Post, Wendy;Astor, Brad
通讯作者：
Astor, Brad
影响因子：
2.2
作者：
Manson JE;Bassuk SS;Lee IM;Cook NR;Albert MA;Gordon D;Zaharris E;Macfadyen JG;Danielson E;Lin J;Zhang SM;Buring JE
通讯作者：
Buring JE
影响因子：
4.7
作者：
通讯作者：
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