Multitissue molecular, genomic, and developmental effects of the Deepwater Horizon oil spill on resident Gulf killifish (Fundulus grandis).
Multitissue molecular, genomic, and developmental effects of the Deepwater Horizon oil spill on resident Gulf killifish (Fundulus grandis).
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DOI：
10.1021/es400458p
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发表时间：
2013-05-21
影响因子：
11.4
通讯作者：
Galvez F
中科院分区：
文献类型：
--
作者：
Dubansky B;Whitehead A;Miller JT;Rice CD;Galvez F
“深水地平线”钻井平台灾难导致墨西哥湾沿岸沿着敏感河口的原油污染。暴露于原油的毒性会影响在受油栖息地生活或繁殖的鱼类种群，正如埃克森巴尔德斯石油泄漏事件后所见。在一项正在进行的关于深水地平线原油对鱼类影响的研究中，从一个受油地点（路易斯安那州格兰德特雷）和两个参考地点（沿海MS和AL）收集了海湾锦鲤（Fundulus grandis），并监测了暴露于原油的措施。与从参考地点收集的鱼相比，从格兰德特雷收集的刀鱼在肝脏和鳃组织中的基因表达与污染油的到达一致，并且在鳃、肝脏、肠和头肾中的细胞色素P4501A（CYP1A）蛋白在油的峰值登陆（2011年8月）后的一年多时间内上调。此外，实验室暴露的海湾鳉鱼胚胎现场收集的沉积物从格兰德特雷和巴拉塔里亚湾，洛杉矶也导致增加CYP1A和发育异常时，暴露于沉积物收集的油污网站相比，暴露于沉积物收集的参考网站。这些数据预测了暴露于墨西哥湾沿岸沿着含油地点沉积物的鱼类种群水平的影响。
The Deepwater Horizon oil rig disaster resulted in crude oil contamination along the Gulf coast in sensitive estuaries. Toxicity from exposure to crude oil can affect populations of fish that live or breed in oiled habitats as seen following the Exxon Valdez oil spill. In an ongoing study of the effects of Deepwater Horizon crude oil on fish, Gulf killifish (Fundulus grandis) were collected from an oiled site (Grande Terre, LA) and two reference locations (coastal MS and AL), and monitored for measures of exposure to crude oil. Killifish collected from Grande Terre had divergent gene expression in the liver and gill tissue coincident with the arrival of contaminating oil, and up-regulation of cytochrome P4501A (CYP1A) protein in gill, liver, intestine and head kidney for over one year following peak landfall of oil (August, 2011) compared to fish collected from reference sites. Furthermore, laboratory exposures of Gulf killifish embryos to field-collected sediments from Grande Terre and Barataria Bay, LA also resulted in increased CYP1A and developmental abnormalities when exposed to sediments collected from oiled sites compared to exposure to sediments collected from a reference site. These data are predictive of population-level impacts in fish exposed to sediments from oiled locations along the Gulf of Mexico coast.
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DOI：
10.1073/pnas.1019031108
发表时间：
2011-04-26
影响因子：
11.1
作者：
Hicken, Corinne E.;Linbo, Tiffany L.;Incardona, John P.
通讯作者：
Incardona, John P.
影响因子：
4.1
作者：
Hontela, A
通讯作者：
Hontela, A
影响因子：
5.8
作者：
Davoodi, Fariba;Claireaux, Guy
通讯作者：
Claireaux, Guy
影响因子：
5.4
作者：
de Soysa TY;Ulrich A;Friedrich T;Pite D;Compton SL;Ok D;Bernardos RL;Downes GB;Hsieh S;Stein R;Lagdameo MC;Halvorsen K;Kesich LR;Barresi MJ
通讯作者：
Barresi MJ
影响因子：
2.5
作者：
Heintz, RA;Rice, SD;Short, JW
通讯作者：
Short, JW