Linking hippocampal multiplexed tuning, Hebbian plasticity and navigation
Linking hippocampal multiplexed tuning, Hebbian plasticity and navigation
复制标题
连接海马多重调节、赫布可塑性和导航
作者：
Jason J. Moore;J. Cushman;Lavanya Acharya;Briana Popeney;M. Mehta
海马功能的三个主要支柱是空间导航1，赫布突触可塑性2和空间选择性3。海马体也与情景记忆有关，但这四种功能之间的精确联系却缺失了。在这里，我们报告的多路选择性背CA1神经元，而大鼠进行虚拟导航任务，仅使用远端视觉线索5，类似于标准的水迷宫测试的空间记忆1。神经反应主要编码的路径距离从起点和头部角度的大鼠，与弱allocentric空间成分类似的灵长类动物，但大大低于啮齿类动物在真实的世界。通常，相同的细胞在序列中复用和编码路径距离、角度和异中心位置，从而编码旅程特异性事件。神经活动和调整的强度与性能密切相关，与时间关系表明神经反应影响行为，反之亦然。与关联和因果赫布学习的计算模型一致6，7，神经反应表现出越来越多的clustering8，并成为行为相关变量的更好的预测因子，平均神经测量曲线超过并收敛到心理测量曲线。因此，海马神经元的多重和表现出高度的可塑性，任务和经验依赖性的调整，以路径为中心的和allocentric变量，形成支持导航的情节序列。情节记忆和allocentric空间导航交织在海马神经元的活动通过赫布可塑性，这使得大鼠编码特定的旅程插曲。
Three major pillars of hippocampal function are spatial navigation1, Hebbian synaptic plasticity2 and spatial selectivity3. The hippocampus is also implicated in episodic memory4, but the precise link between these four functions is missing. Here we report the multiplexed selectivity of dorsal CA1 neurons while rats performed a virtual navigation task using only distal visual cues5, similar to the standard water maze test of spatial memory1. Neural responses primarily encoded path distance from the start point and the head angle of rats, with a weak allocentric spatial component similar to that in primates but substantially weaker than in rodents in the real world. Often, the same cells multiplexed and encoded path distance, angle and allocentric position in a sequence, thus encoding a journey-specific episode. The strength of neural activity and tuning strongly correlated with performance, with a temporal relationship indicating neural responses influencing behaviour and vice versa. Consistent with computational models of associative and causal Hebbian learning6,7, neural responses showed increasing clustering8 and became better predictors of behaviourally relevant variables, with the average neurometric curves exceeding and converging to psychometric curves. Thus, hippocampal neurons multiplex and exhibit highly plastic, task- and experience-dependent tuning to path-centric and allocentric variables to form episodic sequences supporting navigation. Episodic memory and allocentric spatial navigation are interwoven in the activity of hippocampal neuron ensembles via Hebbian plasticity, which allows rats to encode journey-specific episodes.
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DOI：
10.1073/pnas.94.16.8918
发表时间：
1997-08-05
影响因子：
11.1
作者：
Mehta, MR;Barnes, CA;McNaughton, BL
通讯作者：
McNaughton, BL
影响因子：
56.9
作者：
Kentros, C;Hargreaves, E;Muller, RV
通讯作者：
Muller, RV
DOI：
10.1126/science.1244056
发表时间：
2013-11-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Miller JF;Neufang M;Solway A;Brandt A;Trippel M;Mader I;Hefft S;Merkow M;Polyn SM;Jacobs J;Kahana MJ;Schulze-Bonhage A
通讯作者：
Schulze-Bonhage A
解读海马多语言：海马作为路径整合系统。
DOI：
10.1242/jeb.199.1.173
发表时间：
1996
期刊：
The Journal of experimental biology
影响因子：
--
作者：
McNaughton,BL;Barnes,CA;Gerrard,JL;Gothard,K;Jung,MW;Knierim,JJ;Kudrimoti,H;Qin,Y;Skaggs,WE;Suster,M;Weaver,KL
通讯作者：
Weaver,KL
影响因子：
16.6
作者：
Jercog, P. E.;Ahmadian, Y.;Kandel, E. R.
通讯作者：
Kandel, E. R.