Observation of the early blood vessels of cutaneous malignant melanoma using Swept Source Optical Coherence Tomography Angiography (SS-OCTA)

Observation of the early blood vessels of cutaneous malignant melanoma using Swept Source Optical Coherence Tomography Angiography (SS-OCTA)
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使用扫描源光学相干断层扫描血管造影(SS-OCTA)观察皮肤恶性黑色素瘤的早期血管

DOI:
10.1142/s1793545819420057
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发表时间:
2019-08
影响因子:
2.5
通讯作者:
Shi Guohua
Shi Guohua
中科院分区:
医学3区
文献类型:
--
作者:
Liu Jingxuan;Fan Jinyu;Wang Quan;He Wen;Dong Caihua;Sun Minxuan;Shi Guohua

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黑色素瘤是皮肤癌中最典型的恶性肿瘤,具有死亡率高、发展迅速、伴有血管生成等特点。因此,血管的检测具有重要意义。早期血管网规模较小。如果我们早期切除肿瘤并进行活检,会增加癌细胞的扩散、感染和出血。在这种情况下,我们提出了一种新的血管造影方法。提出了一种用于早期皮肤黑色素瘤无创血管成像的高分辨率OCT系统-扫频源光学相干断层血管成像(SS-OCTA)。SS-OCTA具有10[公式:见正文][公式:见正文]m的高横向分辨率,可用于成像和识别早期肿瘤血管的形态。另外,进行对照组实验,观察黑色素瘤生长过程中破裂、微血管畸形情况。分析和统计检验(【公式:见正文】)的结果具有统计学意义。
Melanoma, characterized by high mortality, rapid development and accompanied with angiogenesis is the most typical malignant tumor in skin cancer. Hence, the detection of blood vessels is of much significance. The early vascular network has small scale. If we remove the tumor early and biopsy it, it will increase the spread of the cancer cells and infection and bleeding. In this case, we presented a new angiography method. A high-resolution OCT system for noninvasive angiographic imaging of early skin melanoma — Swept Source Optical Coherence Tomography Angiography (SS-OCTA) is proposed. With a high lateral resolution of 10[Formula: see text][Formula: see text]m in vivo tomographic angiography, SS-OCTA is used to image and identify the morphology of the early tumor blood vessels. In addition, a control group experiment is conducted to observe the growth of melanoma in the process of rupture, malformation of micro-vessels. The results of the analysis and statistical test ([Formula: see text]) are statistically significant.
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