Rapidly in situ forming polyphosphoester-based hydrogels for injectable drug delivery carriers
Rapidly in situ forming polyphosphoester-based hydrogels for injectable drug delivery carriers
复制标题
快速原位形成用于注射药物输送载体的聚磷酸酯基水凝胶
DOI：
10.1039/c2sm25274k
复制
发表时间：
2012-05
期刊：
影响因子：
3.4
通讯作者：
Peihong Ni
中科院分区：
文献类型：
--
作者：
He Jinlin;Zhang Mingzu;Peihong Ni
原位形成水凝胶可以调节物理化学性质，并为生物医学应用提供新的机会。本文报道了一系列具有不同交联度的快速原位形成和 pH 响应性水凝胶的制备和表征，这些水凝胶是通过聚磷酸酯基大交联剂和甲基丙烯酸 2-(二甲氨基)乙酯 (DMAEMA) 单体的加速自由基共聚来实现的。水凝胶的形成可以在温和的条件下非常快地完成，不同浓度的组分需要几分钟到几十分钟。通过开环聚合和聚合后改性相结合的方式合成了聚磷酸酯基大交联剂，并通过 1H NMR、31P NMR 和 GPC 测量对其进行了表征。通过动态时间扫描流变分析监测溶胶-凝胶转变。此外，还对这些水凝胶的溶胀动力学、内部形态、pH响应特性、体外细胞毒性和药物释放进行了表征。结果表明，这些水凝胶作为注射药物输送系统显示出巨大的潜力。
In situ forming hydrogels allow the modulation of physicochemical properties and are providing new opportunities for biomedical applications. Here, the preparation and characterization of a series of rapidly in situ forming and pH-responsive hydrogels with different crosslinking degrees are reported, which were achieved by accelerated free radical copolymerization of polyphosphoester-based macrocrosslinker and 2-(dimethylamino)ethyl methacrylate (DMAEMA) monomer. The hydrogel formation can be completed very quickly under mild conditions, ranging from several to tens of minutes with varying concentrations of components. The polyphosphoester-based macrocrosslinker was synthesized via a combination of ring-opening polymerization and post-polymerization modification, and it was characterized by 1H NMR, 31P NMR, and GPC measurements. The sol–gel transition was monitored by dynamic time sweep rheological analysis. Moreover, the swelling kinetics, interior morphology, pH-responsive property, in vitro cytotoxicity and drug release of these hydrogels were characterized. The results indicate that these hydrogels show great potential as injectable drug delivery system.
登录
查看更多内容
影响因子：
46.2
作者：
Yan C;Pochan DJ
通讯作者：
Pochan DJ
影响因子：
14
作者：
Pritchard, Christopher D.;O'Shea, Timothy M.;Siegwart, Daniel J.;Calo, Eliezer;Anderson, Daniel G.;Reynolds, Francis M.;Thomas, John A.;Slotkin, Jonathan R.;Woodard, Eric J.;Langer, Robert
通讯作者：
Langer, Robert
影响因子：
4.6
作者：
Gorkem Yılmaz;M. Kahveci;Y. Yagcı
通讯作者：
Gorkem Yılmaz;M. Kahveci;Y. Yagcı
影响因子：
9.7
作者：
Layman, Hans;Sacasa, Marianne;Andreopoulos, Fotios M.
通讯作者：
Andreopoulos, Fotios M.
影响因子：
14
作者：
N. Rhodes
通讯作者：
N. Rhodes