A proxy measure of striatal dopamine predicts individual differences in temporal precision.

A proxy measure of striatal dopamine predicts individual differences in temporal precision.
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DOI:
10.3758/s13423-022-02077-1
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发表时间:
2022-08
影响因子:
3.5
通讯作者:
Terhune, Devin B.
Terhune, Devin B.
中科院分区:
心理学2区
文献类型:
--
作者:
Sadibolova, Renata;Monaldi, Luna;Terhune, Devin B.

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时间感知的特点是个体之间的显著差异,这暗示了一系列不同的心理功能。这种变异的神经认知来源尚不清楚,但越来越多的证据表明纹状体多巴胺水平的个体间差异发挥了作用。在这里,我们提出了一项预先注册的研究,该研究测试了自发眨眼率(提供纹状体多巴胺可用性的代理测量)与异常间隔时间(较低的时间精度或高估偏差)相关的预测。神经正常的成年人(N = 69)接受静息状态眼动追踪,并完成视觉心理物理间隔时间和控制任务。自发眨眼频率升高与较差的时间精度有关,但与感知持续时间或控制任务表现的个体间差异无关。这些结果表明纹状体多巴胺在人类时间感知变异性中的作用,并有助于解释以多巴胺水平升高为特征的精神病人群的时间精度不足。在线版本包含补充材料,可在10.3758/s13423-022-02077-1获得。
The perception of time is characterized by pronounced variability across individuals, with implications for a diverse array of psychological functions. The neurocognitive sources of this variability are poorly understood, but accumulating evidence suggests a role for inter-individual differences in striatal dopamine levels. Here we present a pre-registered study that tested the predictions that spontaneous eyeblink rates, which provide a proxy measure of striatal dopamine availability, would be associated with aberrant interval timing (lower temporal precision or overestimation bias). Neurotypical adults (N = 69) underwent resting state eye tracking and completed visual psychophysical interval timing and control tasks. Elevated spontaneous eyeblink rates were associated with poorer temporal precision but not with inter-individual differences in perceived duration or performance on the control task. These results signify a role for striatal dopamine in variability in human time perception and can help explain deficient temporal precision in psychiatric populations characterized by elevated dopamine levels. The online version contains supplementary material available at 10.3758/s13423-022-02077-1.
DOI: 10.1073/pnas.1513619112
发表时间: 2016-01-05
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