Late-acting dominant lethal genetic systems and mosquito control.
Late-acting dominant lethal genetic systems and mosquito control.
复制标题
DOI：
10.1186/1741-7007-5-11
复制
发表时间：
2007-03-20
期刊：
影响因子：
5.4
通讯作者：
Alphey L
中科院分区：
文献类型：
--
作者：
Phuc HK;Andreasen MH;Burton RS;Vass C;Epton MJ;Pape G;Fu G;Condon KC;Scaife S;Donnelly CA;Coleman PG;White-Cooper H;Alphey L
减少或消除病媒种群往往会减少或消除病媒传播疾病的传播。一个潜在的环境友好的方法，物种特定的人口控制是不育昆虫技术（SIT）。SIT尚未被广泛用于防治蚊子等昆虫病媒，部分原因是饲养、消毒和分配方面存在各种实际困难。此外，具有强烈密度依赖效应的病媒种群往往对SIT控制具有抗性，因为诱导不育的种群减少效应往往会被密度依赖死亡率的降低所抵消。我们调查了操纵的发展阶段，死亡发生（致死阶段）在一个SIT程序对密度依赖性有限的昆虫种群的影响，通过数学建模。我们发现，迟效致命性要比早效致命性有效得多。没有这样的菌株的载体昆虫已被描述，所以作为一个证明的原则，我们构建了一个菌株的主要载体的登革热和黄热病病毒，埃及伊蚊（Stegomyia），具有必要的属性占主导地位，抑制，高度渗透，迟效致死。传统的SIT诱导早期作用（胚胎）致死性，但遗传方法可能允许致死阶段是定制的程序。对于昆虫具有较强的密度依赖性，我们表明，致死率后的密度依赖性阶段将是一个相当大的改进，比传统的方法。对于密度依赖性参数估计从现场数据的埃及伊蚊，人口消除的临界释放率被建模为27%至540%以上的早期作用，而不是晚作用的致死率。我们成功地开发了一种蚊子品系，其关键特征表明建模是可取的，这证明了这种方法用于改进SIT以控制疾病的可行性。
Reduction or elimination of vector populations will tend to reduce or eliminate transmission of vector-borne diseases. One potential method for environmentally-friendly, species-specific population control is the Sterile Insect Technique (SIT). SIT has not been widely used against insect disease vectors such as mosquitoes, in part because of various practical difficulties in rearing, sterilization and distribution. Additionally, vector populations with strong density-dependent effects will tend to be resistant to SIT-based control as the population-reducing effect of induced sterility will tend to be offset by reduced density-dependent mortality. We investigated by mathematical modeling the effect of manipulating the stage of development at which death occurs (lethal phase) in an SIT program against a density-dependence-limited insect population. We found late-acting lethality to be considerably more effective than early-acting lethality. No such strains of a vector insect have been described, so as a proof-of-principle we constructed a strain of the principal vector of the dengue and yellow fever viruses, Aedes (Stegomyia) aegypti, with the necessary properties of dominant, repressible, highly penetrant, late-acting lethality. Conventional SIT induces early-acting (embryonic) lethality, but genetic methods potentially allow the lethal phase to be tailored to the program. For insects with strong density-dependence, we show that lethality after the density-dependent phase would be a considerable improvement over conventional methods. For density-dependent parameters estimated from field data for Aedes aegypti, the critical release ratio for population elimination is modeled to be 27% to 540% greater for early-acting rather than late-acting lethality. Our success in developing a mosquito strain with the key features that the modeling indicated were desirable demonstrates the feasibility of this approach for improved SIT for disease control.
登录
查看更多内容
影响因子：
46.9
作者：
Gong, P;Epton, MJ;Alphey, L
通讯作者：
Alphey, L
DOI：
10.1073/pnas.95.13.7520
发表时间：
1998-06-23
影响因子：
11.1
作者：
Handler, AM;McCombs, SD;Saul, SH
通讯作者：
Saul, SH
DOI：
10.1073/pnas.140142697
发表时间：
2000-07-18
影响因子：
11.1
作者：
Heinrich, JC;Scott, MJ
通讯作者：
Scott, MJ
影响因子：
56.9
作者：
Catteruccia, F;Godfray, HCJ;Crisanti, A
通讯作者：
Crisanti, A
影响因子：
2.2
作者：
Amdam, GV;Hartfelder, K;Omholt, SW
通讯作者：
Omholt, SW