Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.
Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.
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DOI：
10.1001/archneurol.2010.197
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发表时间：
2010-09
影响因子：
--
通讯作者：
Cross, Anne H.
中科院分区：
文献类型：
--
作者：
Klawiter, Eric C.;Piccio, Laura;Lyons, Jeri-Anne;Mikesell, Robert;O'Connor, Kevin C.;Cross, Anne H.
评价多发性硬化（MS）受试者和对照者血清和脑脊液（CSF）中髓鞘少突胶质细胞糖蛋白（MOG）的抗体（Ab）。前瞻性病例对照系列。学术推荐中心。26例非炎性神经系统疾病（NIND）对照和35例MS受试者捐献血清和CSF用于rMOG Ab测定。血清和CSF rMOG Ab和白蛋白水平用于计算“rMOG指数”。临床残疾、CSF标志物和磁共振（MR）指标与rMOG指数相关。与对照组相比，MS受试者的rMOG指数升高（p=0.012）。与复发缓解型MS（RRMS）相比，进展型MS受试者表现出rMOG指数升高（p=0.041）。rMOG指数在鉴别MS患者与对照组方面不如IgG指数。然而，16例IgG指数正常的MS受试者中有7例rMOG指数升高。rMOG指数与临床残疾、其他CSF标志物或影像学结局指标无关。rMOG指数是鞘内MOG Ab产生的标志物，可为MS诊断中的常规CSF检测提供补充信息。此外，鞘内抗MOG Ab产生在进展型MS中可能比复发型MS更明显。
Evaluate antibodies (Ab) to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of multiple sclerosis (MS) subjects and controls. Prospective case control series. Academic referral center. Twenty-six controls with non-inflammatory neurologic disease (NIND) and 35 MS subjects donated serum and CSF for rMOG Ab determination. Serum and CSF rMOG Ab and albumin levels were used to calculate an “rMOG index”. Clinical disability, CSF markers, and magnetic resonance (MR) metrics were correlated to rMOG index. rMOG index was elevated in MS subjects compared to controls (p=0.012). Progressive MS subjects exhibited elevated rMOG indices compared to relapsing remitting MS (RRMS) (p=0.041). rMOG index was inferior to IgG index in differentiating MS subjects from controls. However, 7 of 16 MS subjects with normal IgG indices had an elevated rMOG index. rMOG index did not correlate with clinical disability, other CSF markers, or radiographic outcome measures. rMOG index, a marker of intrathecal MOG Ab production, may provide complementary information to routine CSF testing in the diagnosis of MS. Furthermore, intrathecal anti-MOG Ab production may be more pronounced in progressive than relapsing forms of MS.
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DOI：
10.1073/pnas.0510672103
发表时间：
2006-02-14
影响因子：
11.1
作者：
Lalive, PH;Menge, T;Genain, CP
通讯作者：
Genain, CP
影响因子：
3.5
作者：
Fortini, AS;Sanders, EL;Katzmann, JA
通讯作者：
Katzmann, JA
影响因子：
9.9
作者：
Gaertner, S;de Graaf, KL;Weissert, R
通讯作者：
Weissert, R
影响因子：
82.9
作者：
Genain, CP;Cannella, B;Raine, CS
通讯作者：
Raine, CS
影响因子：
3.3
作者：
Brehm, U;Piddlesden, SJ;Linington, C
通讯作者：
Linington, C